MIT Center for Environmental Health Sciences

在这一修订后的申请中，要求提供资金，以继续支持NIEHS中心， 马萨诸塞州理工学院（MIT）的环境健康科学（CEHS）。麻省理工学院CEHS的总体重点是了解有毒环境因子如何干扰生物系统，并确定这种干扰如何影响人类健康。CEHS成立于20世纪70年代初，2001年经历了领导层的更新，现在由Leona Samson和Peter Dedon执导。由于领导层的这一变化，并为回应审查员的批评，该中心已完全重组。目前的CEHS成员包括来自麻省理工学院8个系（科学和工程学院）的32名教师，加上哈佛公共卫生学院（HSPH）的三个系和哈佛医学院（HMS）的一个系。麻省理工学院的系有生物学、化学、生物工程、化学工程、土木与环境工程、机械工程、 工程，核工程，电气工程和计算机科学; HSPH部门是流行病学，营养和环境健康。目前的研究核心，每个由麻省理工学院教授领导，是（i）突变和癌症研究核心（由彼得Dedon领导）;（ii）毒理学研究核心生物工程（由琳达格里菲斯领导）;和（iii）环境系统和健康研究核心（由大卫绍尔领导）。目前的设施核心是（i）生物分析核心（由John Wishnok领导），（ii）基因组学和生物信息学核心（由Peter Sorger领导）和（iii）动物模型和病理学核心（由James Fox领导）。通过这三个设施核心提供的服务包括复杂的质谱、加速器质谱、色谱、转录谱分析和 这些数据的计算分析、转基因和敲除动物生产、病理学服务以及最先进的显微镜和成像。其他单位包括行政核心、试点项目方案和社区外联和教育方案。该中心还共同赞助三个部门研讨会系列，并赞助了CEHS成员研讨会系列，年度务虚会和其他几个机制，旨在培养CEHS成员之间的互动，促进CEHS的活动和麻省理工学院社区对环境健康科学的认识。

In this revised application, funding is requested for the continued support of the NIEHS Center for Environmental Health Sciences (CEHS) at the Massachusetts Institute of Technology (MIT). The overall focus of the MIT CEHS is to understand how toxic environmental agents perturb biological systems and to determine how such perturbations may affect human health. Founded in the early 1970' s, the CEHS underwent a renewal in leadership in 2001 and is now Directed by Leona Samson and Peter Dedon. As a result of this change in leadership and in response to reviewer criticisms, the Center has been completely reorganized. The current CEHS membership consists of 32 faculty members derived from a total of 8 MIT departments (in the Schools of Science and Engineering), plus three Departments in the Harvard School of Public Health (HSPH) and one in the Harvard Medical School (HMS). The MIT departments are Biology, Chemistry, Biological Engineering, Chemical Engineering, Civil & Environmental Engineering, Mechanical Engineering, Nuclear Engineering, Electrical Engineering & Computer Science; the HSPH departments are Epidemiology, Nutrition and Environmental Health. The current Research Cores, each led by an MIT Professor, are (i) the Mutation and Cancer Research Core (led by Peter Dedon); (ii) the Bioengineering for Toxicology Research Core (led by Linda Griffith); and (iii) the Environmental Systems and Health Research Core (led by David Schauer). The current Facilities Cores are (i) the Bioanalytical Core (led by John Wishnok), (ii) the Genomics and Bioinformatics Core (led by Peter Sorger) and (iii) the Animal Models and Pathology Core (led by James Fox). The services available through the three Facilities Cores include sophisticated mass spectrometry, accelerator mass spectrometry, chromatography, transcriptional profiling and computational analysis of such data, transgenic and knock out animal production, pathology services, and state-of the-art microscopy and imaging. Other units include the Administrative Core, the Pilot Project Program and the Community Outreach and Education Program (COEP). The Center also co-sponsors three departmental seminar series, and sponsors a CEHS member seminar series, an annual retreat and several other mechanisms designed to nurture interactions among CEHS members and to promote the activities of the CEHS and an awareness of environmental health science in the MIT community.