Core--Mutation and Cancer

突变和癌症研究核心是为了解决与暴露于环境和内源性化学和物理因素有关的DNA损伤、DNA修复、突变和癌症之间的关系。这里的中心问题之一是环境和内源过程对人类细胞突变负担的贡献程度。 这一核心的具体目标是： (1)进一步发展中心的研究项目和方案，以解决 暴露在环境和内源性因素、基因变化和癌症以及其他疾病之间的机械性联系。 (2)促进突变与癌症研究核心成员之间的互动，以及 本研究核心成员与其他两个研究核心成员之间的互动，目的是创建新的研究项目和方案。 (3)促进CEHS设施核心新技术的开发和获取 这将促进突变和癌症研究核心的研究。

The Mutation and Cancer Research Core was created to address the relationships between DNA damage, DNA repair, mutation and cancer associated with exposure to environmental and endogenous chemical and physical agents. One of the central questions here is the degree to which environmental and endogenous processes contribute to the mutational burdcn of human cells. The Specific Aims of this Core are: (1) To further the development of Center research projects and programs that address the mechanistic linkages between exposure to environmental and endogenous agents, genetic change and cancer, and other diseases. (2) To promote interaction among the members of the Mutation and Cancer Research Core, and interactions between members of this Research Core and those of the other two Research Cores, with the goal of creating new research projects and programs. (3) To promote the development and acquisition of new technologies in the CEHS Facilities Cores that will facilitate studies in the Mutation and Cancer Research Core.