EFFECT OF ENDURANCE EXERCISE ON VLDL-TG METABOLISM

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。耐力运动对健康的生活很重要：它对长期的体重管理是必不可少的，并参与预防心血管疾病(CVD)，可能是通过降低血浆甘油三酯(TG)浓度(无论是在禁食条件下还是在饭后)。在肥胖者中常见的血浆甘油三酯(1，2)水平升高与心血管疾病有直接关系，特别是在女性4，5。根据美国心脏协会最近的一份报告，在美国和大多数发达国家，40%的女性死亡是由心血管疾病引起的，三分之一被认为是由于缺乏运动6。运动导致血浆甘油三酯浓度降低的机制尚不清楚。然而，为了优化预防心血管疾病的治疗方法，最终有必要了解控制血浆甘油三酯浓度的因素。此外，到目前为止，大多数旨在探索运动引起血浆甘油三酯浓度下降的潜在机制的研究(S)都是在精瘦的、经常训练的男性身上进行的，而不是在肥胖者和女性身上进行的。我们7-9和其他10-11发现，性别和肥胖都会影响脂肪代谢，这是对苗条的受试者和男性的研究结果推广的前奏，并强调了专门针对女性和肥胖受试者的研究的重要性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Endurance exercise is important fo a healthy life: it is essential for long term weight management and is involved in the prevention of cardiovascular disease (CVD), presumably via its ability to lower plasma triglyceride (TG) concentrations (both under fasted conditions and after a meal). There is a direct relationship between elevated plasma TG contrations, 1,2, which are commonly observed in obese persons3, and CVD, particularly in women 4,5. According to a recent report by the American Heart Association, >40% of female deaths in the US and most developed countries occur from CVD, one-third is thought to be attributable to inactivity6. The mechanisms that are responsible for the exercise-induced reduction in plasma TG concentrations are not known. In order to optimize therapies for the prevention of CVD, however, it is ultimately necessary to understand the factors that control plasma TG concentrations. Furthermore, most studies that sougth to investigate potential mechanism(s) for the decrease in plasma TG concentration in response to exercise to date have been performed in lean, oftentimes trained, men but not in obese persons and women. We 7-9, and others 10-11, found that both sex and adiposity affect lipik metabolism, which preludes the generalization of findings from lean subjects and men and underlines the importance of studies specifically targeted to women and obese subjects.