EFFECT OF GASTRIC BYPASS ON ADIPONECTIN LEVELS AND INSULIN RESISTANCE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。肥胖的患病率正在急剧上升。随着肥胖人数的增加，与肥胖相关的并发症也在增加。近年来，人们发现脂肪组织在肥胖和2型糖尿病的发病机制中起着关键作用。脂联素是一种脂肪细胞因子，可能是关键因素之一。本研究旨在评估AA和CA合并T2DM患者胃旁路手术前后的脂联素水平和胰岛素抵抗。这将通过测量胃旁路手术前后受试者的脂联素、葡萄糖、CRP、HbA1c、IL-6和tnf - α水平来完成。将测定稳态模型评估（HOMA）胰岛素抵抗（IR）。HOMA -IR是一个用来估计胰岛素抵抗的公式。将招募45名受试者，10名非裔美国人（AA）和35名高加索美国人（CA）。将获得知情同意。脂联素水平存在显著的种族差异可能是AA和CA之间T2DM并发症差异的原因之一。此外，胃分流术前后脂联素水平和胰岛素抵抗的差异可能有助于确定哪些患者最有可能从胃分流术中获益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of obesity is rising dramatically. As the number of obese people increases, so do the complications associated with obesity. In recent years it has been discovered that adipose tissue plays a key role in the pathogenesis of obesity and T2DM. Adiponectin is an adipocytokine that may be one of the key contributors. This study hopes to evaluate adiponectin levels and insulin resistance in both AA and CA with T2DM before and after gastric bypass surgery. This will be accomplished by measuring adiponectin, glucose, CRP, HbA1c, IL-6 and TNF-alpha levels in subjects before and after gastric bypass surgery. Homeostasis model assessment (HOMA) insulin resistance (IR) will be determined. The HOMA -IR is a formula used to approximate insulin resistance. Forty-five subjects, 10 African American (AA) and 35 Caucasian American (CA) subjects, will be recruited. Informed consent will be obtained. The presence of significant ethnic differences in adiponectin levels may be one of the reasons that complications of T2DM vary between AA and CA. Furthermore, differences in adiponectin levels and insulin resistance before and after gastric bypass may help determine which patients are most likely to benefit from gastric bypass surgery.