Oregon Human Investigations Program

说明：说明应用程序的广泛、长期目标和具体目标，并参考该项目与健康相关的内容。描述 简明扼要地介绍实现这些目标的研究设计和方法。避免总结过去的成就和使用第一人称。这篇摘要 是指在与应用程序分开时，作为拟议工作的简洁和准确的描述，如果应用程序得到资助，则此 原样的描述将成为公开信息。因此，不包括专有/机密信息。不要超过空格 但前提是。 过去10年来，临床研究和转化研究的复杂性使更多的人 要求临床研究人员掌握一套新的研究技能。K30资助的人类 调查计划(HIP)成立于四年前，以满足OHSU教职员工和研究员的需求，以及 社区附属机构。该计划由教学部分和指导研究组成。 经验；我们建议在下一个赠款期间增加经验部分。授课课程是 围绕公认的研究核心能力进行开发：临床研究研究设计、生物统计学、 医学信息学，人类研究的伦理，以及科学写作和交流。除了这些，我们还补充说 翻译研究和卫生服务研究。HIP项目的选修课包括数据管理、 随机临床试验、循证医学和有效的临床教学。所有住院期和团契 研究课程已合并到这一计划中。HIP课程由高年级学生创建和教授， 使用成人教育原理的有经验的教育者。在导师的研究经验中，每个学生都是 与导师合作，撰写NIH式的拨款，或设计、实施和撰写关于 临床研究项目。在建议的体验式学习中，HIP学员将有机会参与 在拨款审查、IRB会议或分子生物学实验室工作中，作为例子。所有受训人员在以下时间评估课程： 课程和整个课程在每年年底的焦点小组环境中进行评估。完成 HIP计划授予人类调查培训证书；临床硕士 这项研究已经在俄勒冈州立大学获得批准，目前正在等待俄勒冈大学系统的批准。 目前，HIP已有86人进入学位队列，48人进入非学位队列。在最初的队列中 在攻读学位的31人中，78%的人已经毕业或仍然活跃在该计划中； 在29个队列中，90%仍然活跃；在第三个队列中，26个队列中，96%仍在注册。在第一批完成 根据该计划，80%的人至少提交了一项研究资助，73%的人目前获得了研究资助。 演出现场(S)(组织、市、州) 俄勒冈健康与科学大学，俄勒冈州波特兰 关键人员。请参阅说明。根据需要使用连续页面，以如下所示的格式提供所需信息。 从首席调查员开始。按字母顺序列出所有其他关键人员，姓氏在前。 命名项目中的组织角色 莫里斯，辛西娅，博士，公共卫生硕士，OHSU项目主任 Assael，Leon，DMD OHSU课程主任 小格罗弗·C·巴格比，OHSU医学博士课程主任 贝克尔，托马斯，医学博士，OHSU课程主任 Beemsterboer，Phyllis，MS，EDD OHSU计划评估者 柏林，米歇尔，医学博士，公共卫生硕士，OHSU课程主任 医学博士朱迪思·鲍文，OHSU课程主任 Brandon，David D.，OHSU博士课程主任 陈本雅明，OHSU统计顾问 Chiodo，Gary，DMD，FACD OHSU课程主任 赫尔方德，马克，医学博士，OHSU公共卫生硕士课程主任 披露许可声明。仅适用于SBIR/STTR。请参阅说明。[]是[]否 PHS 398(05/01版)第2页在整个表单第2页底部连续编号 应用时，请勿使用后缀2a、2b。 首席调查项目主任(最后、第一、中间)：Morris，Cynthia D. 名称：组织 威廉·赫什，OHSU医学博士 拉皮德斯，乔迪，俄亥俄大学博士 McCracken，Karen，BA，BSN OHSU 森，元美，OHSU博士 奥沃尔，埃里克·S，OHSU医学博士 玛丽·塞缪尔，OHSU医学博士 舒夫，罗伯特，Ohsu女士 PHS 398/2590(05/01版)第3页 在项目中的角色 课程总监 课程总监 计划协调员 课程总监 课程总监 课程总监 课程总监 续订格式页面 校长/项目主任(最后、第一、中间)：莫里斯、辛西娅·D。 必须在每张打印页和每张续页的顶部提供首席调查员/项目主任的姓名。 研究补助金

DESCRIPTION: State the application's broad, long-term objectives and specific aims, making reference to the health relatedness of the project. Describe concisely the research design and methods for achieving these goals. Avoid summaries of past accomplishmentsand the use of the first person. This abstract is meant to serve as a succinct and accurate descdption of the proposed work when separated from the application, If the application is funded, this description, as is, will become public information. Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE SPACE PROVIDED. The complexities of clinical research and translational research over the past 10 years have placed additional demands for mastery of a new set of research skills for clinical investigators. The K30-funded Human Investigations Program (HIP) was established four years ago to meet the needs of OHSU faculty and fellows, and community affiliates. The program consists of a didactic component coupled with a mentored research experience; we propose to add an experiential component in the next grant period. The didactic courses were developed around the accepted core competencies for research: clinical research study design, biostatistics, medical informatics, ethics of human research, and scientific writing and communication. To these, we add translational research and health services research. Elective courses in the HIP program include data management, randomized clinical trials, evidence-based medicine and effective clinical teaching. All residency and fellowship research courses have been consolidated into this program. The HIP courses are created and taught by senior, experienced educators using principles of adult education. In the mentored research experience, each student is works with a mentor to write either an NIH-style grant or to design, implement, and write a manuscript on a clinical research project. In the proposed experiential learning, HIP trainees will have opportunities to participate in grant review, IRB meetings, or molecular biology lab work, as examples. All trainees evaluate the courses in the curriculum and the entire program is evaluated in a focus group setting at the end of each year. Completion of the HIP program results in awarding a Certificate of Training in Human Investigation; a Master of Clinical Research has been approved at OHSU and is pending approval by the Oregon University System. At present, HIP has enrolled 86 into the degree cohort and 48 into the non-degree cohort. Of the initial cohort of 31 who matriculated in the degree track, 78% have graduated or remain active in the program; of the second cohort of 29, 90% remain active; of the third cohort, of 26, 96% remain enrolled. In the first cohort to complete the program, 80 % have submitted at least one research grant, and 73% currently have research support. PERFORMANCE SITE(S) (organization, city, state) Oregon Health & Science University, Portland, Oregon KEY PERSONNEL. See instructions. Use continuagon pages as needed to provide the required information in the format shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Role on Project Morris, Cynthia D., PhD, MPH OHSU Program director Assael, Leon, DMD OHSU Course director Bagby, Grover C. Jr., MD OHSU Course director Becker, Thomas, MD, PhD OHSU Course director Beemsterboer, Phyllis, MS, EdD OHSU Program evaluator Berlin, Michelle, MD, MPH OHSU Course director Bowen, Judith, MD OHSU Course director Brandon, David D., PhD OHSU Course director Chan, Benjamin, MS OHSU Statistical consultant Chiodo, Gary, DMD, FACD OHSU Course director Helfand, Mark, MD, MPH OHSU Course director Disclosure Permission Statement. Applicable to SBIR/STTR Only. See instructions. [] Yes [] No PHS 398 (Rev. 05/01 ) Page 2 Numberpagesconsecutivelyatthe bottomthroughout Form Page 2 theapplication,Do notuse suffixesuchas 2a, 2b. Principal InvestigatodProgram Director (Last, First, Middle): Morris, Cynthia D. Name Organization Hersh, William, MD OHSU Lapidus, Jodi, PhD OHSU McCracken, Karen, BA, BSN OHSU Mori, Motomi, PhD OHSU Orwoll, Eric S, MD OHSU Samuels, Mary, MD OHSU Schuff, Robert, MS OHSU PHS 398/2590 (Rev. 05/01) Page 3 Role on Project Course director Course director Program Coordinator Course director Course director Course director Course director Continuation Format Page PrincipInavelstigator/Program Director (Last, First, Middle): Morris, Cynthia D. The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT