Self-Gated Cardiac MRI

描述（由申请人提供）：心血管疾病（CVD）是男性和女性的主要死亡原因。磁共振成像（MRI）是一种非常有前途的成像模式，用于检测和表征CVD。已经发现广泛临床应用的主要MRI测试之一是用于评估心脏功能的心血管形态和运动的动态（电影）成像。成功的心脏MRI的主要要求是通过在数据采集期间补偿心脏的运动来减少潜在的图像伪影。这通常通过心电图（ECG）门控和屏气来完成。MR扫描仪内的ECG门控并不总是可靠或对心律失常足够敏感。屏气并不适用于所有患者，并且限制了图像采集时间，因此限制了时间和空间分辨率以及整体图像质量。该项目的目标是通过提供更强大的心动周期同步策略和消除屏气来改善心脏MRI。这将使用自选通策略来完成，该策略从成像数据本身提取运动信息。这可能潜在地允许使用常规技术不可行的患者的心脏MR成像。这些项目的具体目的是验证以下假设：具体目的1：自门控可用于MR电影成像数据与心动周期的稳健回顾性同步，与ECG gatirig相比具有更好的心律失常抑制能力。具体目标二：自选通可用于将图像采集同步到呼吸周期，从而在自由呼吸时实现分段电影MRI。特定目标3：自门控可用于自由呼吸高分辨率3D全心脏电影MRI。特定目标4：自门控可用于MR图像采集与心动周期舒张期的前瞻性同步。

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the leading cause of death in both men arid women. Magnetic resonance imaging (MRI) is a highly promising imaging modality for the detection and characterization of CVD. 1 of the major MRI tests that has found widespread clinical application is the dynamic (cine) imaging of cardiovascular morphology and motion for assessment of cardiac function. A major requirement for successful cardiac MRI is to reduce potential image artifacts by compensating the motion of the heart during data acquisition. This has usually been accomplished by electrocardiogram (ECG) gating and breath-holding. ECG gating within the MR scanner is not always reliable or sufficiently sensitive to arrhythmias. Breath-holding is not feasible in all patients and limits image acquisition time therefore limiting temporal and spatial resolution as well as overall image quality. The objective of the project is to improve cardiac MRI by providing more robust cardiac cycle synchronization strategies and eliminating breath-holding. This will be accomplished using self-gating strategies which extract motion information from the imaging data itself. This may potentially allow for cardiac MR imaging in patients that is not feasible using conventional techniques. The specific aims of the projects are to validate the following hypotheses: Specific Aim 1: Self-gating can be used for robust retrospective synchronization of MR cine imaging data to the cardiac cycle with improved arrhythmia rejection capabilities over ECG gatirig. Specific Aim 2: Self-gating can be used for synchronization of image acquisition to the respiratory cycle allowing segmented cine MRI while free-breathing. Specific Aim 3: Self-gating can be used for free-breathing high resolution 3D whole heart cine MRI. Specific Aim 4: Self-gating can be used for prospective synchronization of MR image acquisition to the diastolic phase of the cardiac cycle.