MBRS-SCORE Program at Hampton University - Supplement

描述（由申请人提供）：最近资助的MBRS-SCORE（1 S 0-GM 66093 -01）被设想为汉普顿大学校园内的生物医学研究恢复活力的工具。该计划的根本目标是一个充满活力和可持续的生物医学研究计划的肆无忌惮的发展。预计该MBRS-SCORE计划将有助于在汉普顿大学建立生物医学研究科学家的“临界质量”，使该机构能够更好地成功参与公开的研究赠款竞争。拟议方案的另一个基本目标是培训少数民族教师和学生进行生物医学研究。将组织和推广一系列“尖端”研讨会和讲习班，使整个汉普顿大学的研究界都能参与。据预计，这MBRS-SCORE研究补充的收购将进一步加强药学院的研究基础设施，它无疑将沉淀在汉普顿大学的研究基础设施的巨大改善。在这个项目中，我们建议开发一种与电喷雾质谱联用的纳米流HPLC方法，以准确定量阿尔茨海默病患者血清中的Abeta 40和Abeta 42水平。我们还计划使用蛋白质组学方法来定性分析人血清中的氨基截短的Abeta肽种类。该项目的结果将为进一步研究血清中Abeta沉积与阿尔茨海默病发展之间的联系奠定基础。从该项目中获得的信息可能为了解阿尔茨海默病的病理机制提供新的途径，最终导致生物标志物的鉴定，这可能会增强阿尔茨海默病的诊断和治疗。这一补充肯定有助于实现MBRS-SCORE原始提案中概述的目标和目的。

DESCRIPTION (provided by applicant): The recently funded MBRS-SCORE (1 S0-GM66093-01) is envisioned to be the vehicle by which biomedical research on the campus of Hampton University is rejuvenated. The underlying goal of this program is the unbridled development of a vigorous and sustainable biomedical research program. It is anticipated that this MBRS-SCORE Program will serve to create a "critical mass" of biomedical research scientist at Hampton University, such that the institution will be better poised to successfully participate in open competition for research grants. Another underlying objective of the proposed program is the training of minority faculty and students in biomedical research. A series of "cutting-edge" seminars and workshops will be organized and promoted, so that the entire Hampton University research community can participate. It is anticipated that the acquisition of this MBRS-SCORE Research Supplement will further enhance the research infrastructure in the School of Pharmacy, and it will undoubtedly precipitate a monumental improvement in the research infrastructure at Hampton University. In this project we propose to develop a nanoflow HPLC method coupled with electrospray mass spectrometry to accurately quantitate Abeta40 and Abeta42 levels in human blood serum in patients with Alzheimer's disease. We also plan to use a proteomics approach to qualitatively analyze amino-truncated Abeta peptide species in human blood serum. The results from this project will establish the groundwork to further investigate the link between Abeta deposition in blood serum with the development of Alzheimer's disease. The information obtained from this project may provide a new avenue to understand the pathological mechanism of Alzheimer's disease, ultimately leading to the identification of biomarkers, which could enhance the diagnosis and treatment of Alzheimer's disease. This supplement will definitely facilitate the realizations of the goals and objectives outlined in the original MBRS-SCORE proposal.