MBRS SCORE Program at the Ponce School of Medicine

庞塞医学院的 MBRS SCORE 项目

• 批准号: 7919934
• 负责人: Jaime L Matta
• 金额: $ 34.47万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-10 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7919934
• 关键词: MBRS; SCORE; Program; Ponce; Medicine

In the present application we are requesting funds to continue the support of the MBRS SCORE'. Program at the Ponce School of Medicine. The MBRS SCORE Program, since its implementation in 19854, has been the driving force in developing and strengthening the graduate program in Biomedical Sciences and in creating a vigorous research environment that has resulted in providing the resources to support studies in immunology, cellular and molecular biology, epidemiology, parasitology, toxicology neurosciences, HIV/AIDS, and human physiology. The goal of this MBRS-SCORE Program proposal is to increase the biomedical research productivity, the scientific competitiveness and recognition of the faculty, by providing first rate research and development opportunities and in creating a stimulating research atmosphere in this Institution. The proposal contains a total of twenty regular subprojects and three pilot projects involving more than thirty-seven investigators, seven of which have been recently recruited into the School. The subprojects that make up this Program includes basic, psychological, and clinical research initiatives from faculty in the departments of Biochemistry, Microbiology, Pharmacology and Toxicology, Physiology, Clinical Psychology, and Public Health. The diverse projects include such areas as human genetics, protein folding, neurosciences, cancer biology, asthma, aging, signal transduction, cancer, gastrointestinal physiology, toxicology, HIV/AIDS, neuroscience, endometriosis, epidemiology, and psychology. These research projects will be sustained by an administrative component and by technical support personnel that includes collaborators, consultants, research associates, laboratory supervisors and research assistants. In addition, some of the activities will be complementary to other minority targeted programs in the Institutions such as the NIH-RCMI Program. Progress in the Specific Aims of each subproject and in the overall aims of the Program will be evaluated yearly in a formative report, and at the end in a summative document. Progress and achievements of the proposed program will be assessed continuously through an ongoing formative evaluation intended to provide information to improve the performance in the various program subprojects and through a summative evaluation that will finally assess the Program's success and the extent to which the completed project has met its goals. Both the evaluation of the implementation to assess whether the Program is being conducted as planned and the process, the

在本应用程序中，我们要求资金继续支持MBRS分数。 Ponce的计划 医学院。自19854年实施以来，MBRS得分计划一直是推动力 制定和加强生物医学科学领域的研究生课程并创作有力的研究 导致提供资源来支持免疫学，细胞和分子研究的环境 生物学，流行病学，寄生虫学，毒理学神经科学，艾滋病毒/艾滋病和人类生理学。目标的目标 MBRS得分计划的建议是提高生物医学研究生产力，科学竞争力 并通过提供一流的研发机会并创建一个级别的研究和发展机会，并建立一个教师的认可 刺激该机构的研究氛围。该提案总共包含二十个常规次要标题， 三个涉及37多名调查人员的试点项目，其中7名已被招募到 学校。构成该计划的子弹包括基本，心理和临床研究计划 来自生物化学，微生物学，药理学和毒理学，生理学，临床学系 心理学和公共卫生。各种项目包括人类遗传学，蛋白质折叠， 神经科学，癌症生物学，哮喘，衰老，信号转导，癌症，胃肠道生理学，毒理学，毒理学， 艾滋病毒/艾滋病，神经科学，子宫内膜异位症，流行病学和心理学。 这些研究项目将由行政组成部分和技术支持人员维持 包括合作者，顾问，研究助理，实验室主管和研究助理。此外， 其中一些活动将与诸如机构的其他少数群体针对的计划互补 NIH-RCMI计划。每个副本的具体目的以及该程序的总体目标的进展将是 每年在形成性报告中进行评估，最后在一份总结文件中进行评估。进步和成就 拟议的计划将通过旨在提供的持续的形成性评估来连续评估 信息以提高各种计划的绩效，并通过总结性评估 最终将评估该计划的成功以及完成项目实现其目标的程度。两者 评估实施的评估，以评估该计划是否按计划进行和过程，以及该过程，

项目成果

The suppression of T cell function and NF(kappa)B expression by serine protease inhibitors is blocked by N-acetylcysteine.

N-乙酰半胱氨酸可阻断丝氨酸蛋白酶抑制剂对 T 细胞功能和 NF(kappa)B 表达的抑制。

• DOI: 10.1006/cimm.1996.0258
• 发表时间: 1996
• 期刊: Cellular immunology
• 影响因子: 4.3
• 作者: Breithaupt,TB;Vazquez,A;Baez,I;Eylar,EH
• 通讯作者: Eylar,EH

Immunoblot analysis and comparative IgE responses of atopic patients to extracts of the domestic mite Blomia tropicalis.

特应性患者对家螨热带螨提取物的免疫印迹分析和比较 IgE 反应。

• 发表时间: 2006
• 期刊: Puerto Rico health sciences journal
• 影响因子: 0.5
• 作者: Montealegre,Federico;Goth,Kerstin;Hart,Barbara
• 通讯作者: Hart,Barbara

The association of DNA Repair with breast cancer risk in women. A comparative observational study.

• DOI: 10.1186/1471-2407-12-490
• 发表时间: 2012-10-22
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Matta J;Echenique M;Negron E;Morales L;Vargas W;Gaetan FS;Lizardi ER;Torres A;Rosado JO;Bolaños G;Cruz JG;Laboy J;Barnes R;Medina SS;Romero A;Martinez R;Dutil J;Suarez E;Alvarez-Garriga C;Bayona M
• 通讯作者: Bayona M

HIV infection and aging: enhanced Interferon- and Tumor Necrosis Factor-alpha production by the CD8+ CD28- T subset.

• DOI: 10.1186/1471-2172-2-10
• 发表时间: 2001
• 期刊: BMC immunology
• 影响因子: 3
• 作者: Eylar EH;Lefranc CE;Yamamura Y;Báez I;Colón-Martinez SL;Rodriguez N;Breithaupt TB
• 通讯作者: Breithaupt TB

Cloning and molecular characterization of a cDNA from Blomia tropicalis homologous to dust mite group 3 allergens (trypsin-like proteases).

与尘螨第 3 组过敏原（胰蛋白酶样蛋白酶）同源的热带布洛米亚 cDNA 的克隆和分子表征。

• DOI: 10.1159/000068375
• 发表时间: 2003
• 期刊: International archives of allergy and immunology
• 影响因子: 2.8
• 作者: Flores,Idhaliz;Mora,Carlos;Rivera,Elizabeth;Donnelly,Robert;Montealegre,Federico
• 通讯作者: Montealegre,Federico