Training in Pharmacometrics and the Therapeutic Application of Nanotechnology

描述（由申请人提供）：本申请的儿科药理学指导专业临床研究者发展奖（MSCIDA）的主要目的是为帕特里克A博士提供儿科临床药理学方面的全面培训计划。汤普森说，一个符合董事会资格的儿科医生和血液肿瘤学的子专业研究员。帕特里克在工程、数学建模和临床医学方面有着独特的背景。汤普森博士的这一全面培训计划是为1）进一步发展他在药代动力学建模和药代动力学，药效学和药物遗传学相关性方面的能力，2）为他提供设计，实施和分析儿科临床治疗试验的知识和能力，3）让他全面了解与儿科药物和生物学标签相关的复杂监管问题，（4）教他进行药理学的转化研究。他的培训将通过贝勒医学院（Baylor College of Medicine）的儿科药理学研究单位（PRRU）进行，并将包括在美国临床药理学委员会注册的临床药理学奖学金计划的正式注册。临床药理学奖学金计划课程涵盖了MSCIDA奖项所要求的所有主题。它包括参与美国国家卫生研究院，NIH-K30资助的临床科学家培训计划（CSTP），休斯顿大学药学院的正式课程，以及通过德克萨斯大学和德克萨斯儿童医院的临床轮换。该奖学金的教学部分还包括在食品和药物管理局，制药行业，以及在合作PPRU网站的基于人口的建模专家的外部轮换。Thompson博士职业规划的研究部分包括两个项目：1）一个药理学项目，利用群体建模技术评估一种重要抗癌药物伊立替康的药代动力学变异性; 2）一个项目，描述两种类型的治疗性抗体靶向金纳米颗粒的药理学和生物分布，这些纳米颗粒具有治疗恶性肿瘤或其他疾病过程的前景。汤普森博士的拟议职业发展计划将为实现他成为儿科临床药理学领先的临床科学家和教育家的长期目标奠定良好的基础。

DESCRIPTION (provided by applicant): The primary aim of this application for the Mentored Specialized Clinical Investigator Development Award (MSCIDA) in Pediatric Pharmacology is to provide a comprehensive training program in pediatric clinical pharmacology for Dr. Patrick A. Thompson, a board-eligible pediatrician and sub-specialty fellow in hematology-oncology. Patrick has a unique background in engineering, mathematical modeling and clinical medicine. This comprehensive training program for Dr. Thompson has been tailored to 1) further develop his capabilities in pharmacokinetic modeling and pharmacokinetic, pharmacodynamic and pharmacogenetic correlations, 2) provide him with the knowledge and ability to design, conduct, and analyze pediatric clinical therapeutics trials, 3) give him a thorough understanding of the complex regulatory issues associated with pediatric labeling of drugs and biology, and 4) teach him to carry out translational research in pharmacology. His training will occur through Baylor College of Medicine's( BCM) Pediatric Pharmacology Research Unit (PRRU) and will include formal enrollment in the BCM Clinical Pharmacology Fellowship Program, which is registered with the American Board of Clinical Pharmacology. The BCM Clinical Pharmacology fellowship program curriculum covers all the topics required by the MSCIDA award. It includes participation in BCM's, NIH-K30 grant-supported Clinical Scientist Training Program (CSTP), formal coursework at the University of Houston College of Pharmacy, and clinical rotations through the University of Texas and Texas Children's Hospital. The didactic component of this fellowship also includes outside rotations at the Food and Drug Administration, with the pharmaceutical industry, and with experts in population-based modeling at a collaborating PPRU site. The research component of Dr. Thompson's career plan includes two projects: 1) a pharmacometric project to evaluate the pharmacokinetic variability of an important anticancer agent, irinotecan, utilizing population modeling techniques; and 2) a project to characterize the pharmacology and biodistribution of two types of therapeutic antibody-targeted gold nanoparticles that have promising applications for the treatment of malignant or other disease processes. The proposed Career Development Plan for Dr. Thompson will provide an excellent foundation for achieving his long-term goal of becoming a leading clinician-scientist and educator in pediatric clinical pharmacology.