Pediatric Oncology Clinical Research Training Program

描述（由申请人提供）：本提案构成了由贝勒医学院德克萨斯儿童癌症中心开发的儿科肿瘤临床研究培训计划（POCRTP）的续期申请。该培训计划的前提是，在临床研究方面受过高度训练的儿科肿瘤学家和儿科肿瘤学护士的发展对儿童癌症治疗的持续进步至关重要。此更新申请突出了过去十年中所招募的学者的令人印象深刻的学术成就和进步。该计划旨在提供一个正式的、全面的、多学科的临床研究教育计划，培训(1)完成了三年儿科血液学肿瘤学奖学金培训计划并在该亚专业获得董事会资格或认证的儿科医生；(2)对儿科肿瘤学临床研究感兴趣的博士护士。这个“单轨”项目的学员被指定为“保罗·卡拉布雷西学者”。他们在临床研究试验的设计、实施、实施和分析方面接受两到三年的综合教学指导培训。该计划强调在团队研究环境中进行治疗研究的培训，在团队研究环境中，基础和临床科学家相互作用，以加快基础研究发现向患者导向的转化

DESCRIPTION (provided by applicant): This proposal constitutes the renewal application of the Pediatric Oncology Clinical Research Training Program (POCRTP), developed by Baylor College of Medicine's Texas Children's Cancer Center. This training program is predicated on the premise that the development of pediatric oncologists and pediatric oncology nurses who are highly trained in clinical research is essential for continued progress to be made in the treatment of childhood cancer. This renewal application highlights the impressive academic accomplishments and progress of the individual Scholars recruited during the last ten years. The program is structured to provide a formal, comprehensive, multidisciplinary clinical research educational program that trains (1) pediatricians who have completed a three-year pediatric hematology-oncology fellowship training program and are board eligible or certified in that subspecialty and, (2) Ph.D. nurses with a career interest in pediatric oncology clinical research. Trainees, in this "one-track" program, are designated "Paul Calabresi Scholars". They receive a two to three year comprehensive, didactic mentored training experience in the design, implementation, conduct and analysis of clinical research trials. The program emphasizes training in therapeutic research that occurs in team research settings in which basic and clinical scientists interact to expedite the translation of basic research discoveries into patient-oriented therapeutic cancer research. The program includes participation in a core didactic course in clinical investigation and trial design, provided through Baylor College of Medicine's Clinical Scientist Training Program, and an in-depth clinical research training experience focused in one of five specialized research areas, designated "Pathways", chosen by the trainee. The POCRTP Pathways include Clinical Pharmacology, Neuro-oncology, Cell and Gene Therapy, Hematologic Malignancy or Solid Tumors. The research experience within each Pathway is tailored to meet the individual Scholar's long-term research goals. All Scholars receive comprehensive mentorship by both a laboratory research and a clinical research mentor and receive in depth instruction in clinical trial design, statistical analysis, research ethics and regulatory requirements and guidelines. In addition, Scholars design and conduct clinical trials in their respective Pathways. An elective rotation at the National Cancer Institute's Cancer Therapy Evaluation Program is a feature of this program. The experience to date indicates that Scholars who complete this program are exceptionally well trained in clinical research, very successful in obtaining NIH funding and well positioned to become future leaders in pediatric oncology clinical research.