EPC mediated Neovascularization in Ischemic Myocardium

描述（由申请人提供）：缺血性心肌病（ICM）是一种日益普遍的全球健康问题。内皮祖细胞（EPC）介导的新生血管可能提供一种增加缺血心肌侧支循环的手段，从而改善心功能。用粒细胞-单核细胞集落刺激因子（GM-CSF）刺激全身骨髓以诱导EPC增殖，结合基质细胞衍生因子（SDF）靶向心肌EPC趋化作用的策略将用于增强缺血心肌内的新血管生成。利用已建立的ICM大鼠模型获得的初始数据已证明，在用GM-CSF和SDF组合治疗的大鼠中，心肌收缩力和新血管形成增强。拟议的研究将试图阐明SDF作为增强心肌新生血管形成的新手段的作用，特别关注EPC动员、心肌灌注、缺血逆转、增强心肌功能和有限的心室重塑与几何形状的保留。

DESCRIPTION (provided by applicant): Ischemic cardiomyopathy (ICM) is an increasingly prevalent global health concern. Endothelial progenitor cell (EPC) mediated neo-vascularization may provide a means to increase collateral circulation in ischemic myocardium, thereby improving cardiac function. A strategy of global bone marrow stimulation with granulocyte-monocyte colony stimulating factor (GM-CSF) to induce EPC proliferation combined with stromal cell-derived factor (SDF) targeted myocardial EPC chemokinesis will be utilized to enhance neovasculogenesis within ischemic myocardium. Initial data obtained utilizing an established rat model of ICM has demonstrated enhanced myocardial contractility and neovascularization among rats treated with a combination of GM-CSF and SDF. The proposed research will attempt to elucidate the role of SDF as a novel means of enhancing myocardial neovascularization specifically focusing on EPC mobilization, myocardial perfusion, ischemia reversal, enhanced myocardial function, and limited ventricular remodeling with preservation of geometry.