Cross-Sensory Selective Attention

描述（由申请人提供）： 基于特征的选择性注意的神经生理学研究几乎完全集中在单一的感觉模态中。然而，在真实的世界中，相关的对象往往是在多个感官系统中指定的，这可能导致选择性地关注多个感官系统的输入。很明显，要全面理解选择性注意过程，就需要在受试者关注不同感觉系统的相关特征的条件下，对选择性注意的神经生理学进行研究。这项建议的主要目的是应用高时间分辨率的电生理记录与功能磁共振成像的精细空间分辨率，在相同的任务条件下，为了表征跨感觉选择性注意机制的时间过程和神经解剖学基板的大量文献单感觉选择性注意。重要的是，这项工作将扩展到精神分裂症患者，以描述这一人群中选择性注意力缺陷的神经生理学特征。我们将使用Hillyard（1973）的选择性注意范式的一个变体。最终，跨感觉选择性注意的神经生理学研究结果将提供一个更完整的注意过程的图片，并增加了理解精神分裂症患者注意功能障碍的基础。

DESCRIPTION (provided by applicant): Work on the neurophysiology of feature-based selective attention has almost exclusively been focused within a single sensory modality. Yet in the real world relevant objects are often specified in more than sense, and this likely results in selectively attending to inputs across multiple sensory systems. Clearly a full understanding of selective attention processes requires that the neurophysiology of selective attention be studies under conditions in which subjects are attending to related features across sensory systems. The primary aim of this proposal is to apply the high temporal resolution of electrophysiological recordings with the fine spatial resolution of functional magnetic resonance imaging, under identical task conditions, in order to characterize both the time course and neuroanatomical substrates of cross-sensory selective attention mechanisms in relation to the vast literature on uni-sensory selective attention. Importantly, this work will be extended to schizophrenia patients, to characterize the neurophysiology of selective attention deficits in this population. A variation of the selective attention paradigm of Hillyard (1973) will be used. Ultimately, findings on the neurophysiology of cross-sensory selective attention will provide a more complete picture of attentional processes, and add to the basis for understanding attentional dysfunction in patients with schizophrenia.