Phase I/II Partnership in Biomedical Discovery

描述（由申请人提供）： 这个第一/第二阶段项目的总体目标是通过向高中教师和学生介绍基于探究的过程，即科学研究，开发一个研究型大学的科学专业知识如何直接影响当地K-12科学教育的模型。我们的基本前提是，真正的科学知识需要积极参与科学探究，这样参与的教师和学生可以成为科学教育变革的推动者。为此，我们建议将选定的生物学教师和高中生沉浸在为期8周的夏季研究体验中，在此期间，他们直接参与大学环境中的前沿研究。在九个大学研究实验室的参与和指导下，教师和学生团队将在一个实验室设施中使用三组模型生物进行新突变的遗传筛查：细菌，酵母和C。优雅虽然这些研究实验室有不同的目标，并采用不同的实验方法和不同的技术，有一个共同的线索，他们使用遗传学的方法和范式来研究与健康有关的问题的兴趣和关注的公众。参与教师、教师咨询委员会和大学教师之间的每周课程圆桌会议将侧重于开发基于调查的教育模块和实验包，这些模块和实验包以这些模式生物为基础，供高中和初中课堂使用，并侧重于评估这些模块的影响的方法和机制。这些模块将在为期一周的课程研讨会上进行测试，完善和传播，高中教师（谁没有做过研究经验）在项目年2-5。在接下来的几年里，我们将为高中班级提供实验工具包，让参加过我们项目的教师可以实施基于探究的课程模块。项目评估的目的是比较教师谁做了为期8周的研究经验与那些谁做了为期一周的课程研讨会，关于采用和有效利用的调查为基础的方法和模块，跟踪学生参与者的教育和职业道路，并评估在高中生物学习的影响。

DESCRIPTION (provided by applicant): The overall objective of this phase I/II project is to develop a model of how the scientific expertise of a research university can directly impact local K-12 science education, by introducing high school teachers and students to the inquiry-based process that is scientific research. Our fundamental premises are that true science knowledge requires active engagement in scientific inquiry, and that teachers and students so engaged can become agents of change in science education. To this end, we propose to immerse selected biology teachers and high school students in an 8-week summer Research Experience, during which they participate directly in cutting-edge research in a University environment. With the participation and guidance of nine University research labs, teacher-student teams in a single lab facility will perform genetic screens for new mutations using three sets of model organisms: bacteria, yeast and C. elegans. Although these research labs have diverse objectives and employ varied experimental approaches and different techniques, there is a common thread in that they use the methods and paradigms of genetics to study health-related problems of interest and concern to the public. Weekly Curriculum Roundtable meetings among participating teachers, a Teacher Advisory Board and University faculty will focus on developing inquiry-based education modules and experiment kits, based on these model organisms, for use in high school and middle-school classrooms, and on methods and mechanisms for assessing the impact of such modules. The modules will be tested, refined and disseminated in one-week Curricular Workshops for high school teachers (who have not done the Research Experience) in project years 2-5. During succeeding years, we will provide experiment Kits for high school classes, with which teachers who have been through our programs can implement the inquiry-based curricular modules. Project evaluations aim to compare teachers who have done the 8-week Research Experience with those who have done the one-week Curricular Workshop, with respect to adoption and effective use of the inquiry-based methods and modules, to track educational and career paths of student participants, and to assess the impact on learning in high school biology.