Clinical Research & Patient Care Core (CRPCC)

临床研究

• 批准号: 10588232
• 负责人: Larry S. Schlesinger
• 金额: $ 12.83万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-10 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588232
• 关键词: Address; Ambulatory Care Facilities; Biomedical Research; Caring; Cause of Death; Chest; Cities; Clinic; Clinical; Clinical Management; Clinical Research; Clinical Services; Collection; Communicable Diseases; Communication; Communities; Complex; Consultations; Country; Data; Data Analyses; Development; Diabetes Mellitus; Discipline; Education; Educational Curriculum; Epidemiology; Ethics; Evaluation; Extreme drug resistant tuberculosis; Field Workers; Foundations; Funding; Funding Agency; Future; Health; Health Professional; Homelessness; Hospitals; Human Subject Research; Hybrids; Incidence; Infrastructure; Inpatients; Institution; Knowledge; Laboratories; Leadership; Learning; Length of Stay; Logistics; Medical; Mentors; Mexican; Mexico; Mission; Multidrug-Resistant Tuberculosis; Non-Insulin-Dependent Diabetes Mellitus; Oral; Outpatients; Participant; Pathogenesis; Patient Care; Patients; Persons; Physicians; Pilot Projects; Population; Prevention strategy; Qualitative Evaluations; Quantitative Evaluations; Research; Research Design; Research Institute; Research Personnel; Research Training; Resources; Rotation; Science; Side; Site; Social Problems; South Texas; Specimen; Specimen Handling; Structure; Texas; Thoracic Radiography; Training; Treatment outcome; Tuberculosis; Universities; Vaccines; Work; Writing; biocontainment facility; clinical care; clinical center; clinical research site; comorbidity; critical period; curriculum enhancement; design; diagnostic strategy; experience; field study; human old age (65+); improved; interdisciplinary approach; interdisciplinary curriculum; interest; laboratory experiment; member; metropolitan; multidisciplinary; next generation; participant enrollment; peer; prevent; programs; prospective; research study; skills; social; success; therapy adverse effect; tool; transmission process; treatment strategy; tuberculosis diagnostics; tuberculosis treatment; virtual

IN-TRAC Clinical Research & Patient Care Core (CRPCC) ABSTRACT Tuberculosis (TB) is a leading infectious disease cause of death worldwide. In the US, TB incidence rates are historically low, but control remains challenging in certain populations, including the communities along the US border with Mexico. Thus, there is an urgent need for the next generation of TB researchers to have an understanding of the clinical and epidemiological aspects of TB research, as a foundation for their future leadership in the development of improved TB diagnostics, surveillance, treatments and vaccines. The Clinical Research & Patient Care Core (CRPCC) of the IN-TRAC will provide to New TB Investigators (NIs) and investigators new to the TB field, the infrastructure, resources and training in TB clinical research, and education on the challenges faced by clinicians in managing TB cases. Our training sites are strategically located in south Texas, a state adjacent to Mexico, which is the number one country of origin for foreign-born TB cases in the US. The TB clinical research site is led by Dr. Restrepo, an expert in TB field epidemiology and pathogenesis in TB patients with diabetes comorbidity or old age. Her field site is unique within the US due to its access to TB patients enrolled on the Mexican side of the Texas border. The TB patient care training will be in San Antonio, led by Drs. Armitige and Seaworth, an exemplary team of physicians who are affiliated with the only free-standing TB hospital in the US, the Texas Center for Infectious Diseases (TCID). In the same setting, there are also busy outpatient clinics: The San Antonio Metropolitan Health Department Chest Clinic, and a TB regional training and medical consultation Center of Excellence (The Heartland National TB Center; HNTBC). Our Aims are to: Aim 1. Execute a personalized training curriculum on TB clinical research studies. We have designed a hybrid (hands-on and virtual) training curriculum for IN-TRAC participants on all aspects of Clinical TB Research, including ethics, study design, field logistics, data and specimen management, specimen processing and data analysis plans and communications. Aim 2. Execute a personalized training curriculum on TB patient care. IN-TRAC participants will be educated on the complex set of decisions that physicians make, particularly during the management of difficult TB cases (e.g. with DR-TB, or with social problems such as homelessness), and who require specialized management and prolonged in-hospital stays. The mentoring team will meet with each IN-TRAC participant prior to their rotation to discuss customization of the core curriculum, including the development of a pilot project, depending on the IN-TRAC participant’s interest. IN-TRAC participants will provide a written and oral evaluation of their training experience.

IN-TRAC 临床研究和患者护理核心 (CRPCC) 摘要 结核病 (TB) 是全球主要的传染病死因。在美国，结核病发病率为 处于历史低位，但对某些人群（包括美国沿线社区）的控制仍然具有挑战性 与墨西哥接壤。因此，下一代结核病研究人员迫切需要拥有 了解结核病研究的临床和流行病学方面，为他们的未来奠定基础 在开发改进的结核病诊断、监测、治疗和疫苗方面发挥领导作用。临床 IN-TRAC 的研究与患者护理核心 (CRPCC) 将为新结核病研究者 (NI) 和 结核病领域的新研究者、结核病临床研究和教育方面的基础设施、资源和培训 临床医生在管理结核病病例时面临的挑战。我们的培训地点战略性地位于南部 德克萨斯州，毗邻墨西哥，是美国外国出生结核病病例的第一大原产国 我们。结核病临床研究中心由雷斯特雷波博士领导，他是结核病现场流行病学和发病机制专家。 患有糖尿病合并症或年老的结核病患者。她的现场站点因其可访问结核病而在美国独一无二 患者在德克萨斯州边境的墨西哥一侧登记。结核病患者护理培训将在圣安东尼奥举行， 由博士领导。 Armitige 和 Seaworth 是一支模范医生团队，隶属于唯一的独立机构 美国结核病医院德克萨斯传染病中心（TCID）。在同样的环境下，也有繁忙的 门诊诊所：圣安东尼奥市卫生局胸部诊所以及结核病区域培训和 卓越医疗咨询中心（哈特兰国家结核病中心；HNTBC）。我们的目标是： 目标 1. 实施结核病临床研究的个性化培训课程。我们设计了一种混合动力 为 IN-TRAC 参与者提供有关临床结核病研究各个方面的（实践和虚拟）培训课程， 包括伦理、研究设计、现场后勤、数据和样本管理、样本处理和数据 分析计划和沟通。目标 2. 实施有关结核病患者护理的个性化培训课程。 IN-TRAC 参与者将接受关于医生做出的一系列复杂决策的教育，特别是在 疑难结核病病例的管理（例如耐药结核病或无家可归等社会问题），以及 需要专门管理和长期住院的人。 指导团队将在每位 IN-TRAC 参与者轮换之前与他们会面，讨论定制化方案 核心课程，包括开发试点项目，具体取决于 IN-TRAC 参与者的兴趣。 IN-TRAC 参与者将对他们的培训经历进行书面和口头评估。