Clinical Research & Patient Care Core (CRPCC)

临床研究

• 批准号: 10588232
• 负责人: Larry S. Schlesinger
• 金额: $ 12.83万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-10 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588232
• 关键词: Address; Ambulatory Care Facilities; Biomedical Research; Caring; Cause of Death; Chest; Cities; Clinic; Clinical; Clinical Management; Clinical Research; Clinical Services; Collection; Communicable Diseases; Communication; Communities; Complex; Consultations; Country; Data; Data Analyses; Development; Diabetes Mellitus; Discipline; Education; Educational Curriculum; Epidemiology; Ethics; Evaluation; Extreme drug resistant tuberculosis; Field Workers; Foundations; Funding; Funding Agency; Future; Health; Health Professional; Homelessness; Hospitals; Human Subject Research; Hybrids; Incidence; Infrastructure; Inpatients; Institution; Knowledge; Laboratories; Leadership; Learning; Length of Stay; Logistics; Medical; Mentors; Mexican; Mexico; Mission; Multidrug-Resistant Tuberculosis; Non-Insulin-Dependent Diabetes Mellitus; Oral; Outpatients; Participant; Pathogenesis; Patient Care; Patients; Persons; Physicians; Pilot Projects; Population; Prevention strategy; Qualitative Evaluations; Quantitative Evaluations; Research; Research Design; Research Institute; Research Personnel; Research Training; Resources; Rotation; Science; Side; Site; Social Problems; South Texas; Specimen; Specimen Handling; Structure; Texas; Thoracic Radiography; Training; Treatment outcome; Tuberculosis; Universities; Vaccines; Work; Writing; biocontainment facility; clinical care; clinical center; clinical research site; comorbidity; critical period; curriculum enhancement; design; diagnostic strategy; experience; field study; human old age (65+); improved; interdisciplinary approach; interdisciplinary curriculum; interest; laboratory experiment; member; metropolitan; multidisciplinary; next generation; participant enrollment; peer; prevent; programs; prospective; research study; skills; social; success; therapy adverse effect; tool; transmission process; treatment strategy; tuberculosis diagnostics; tuberculosis treatment; virtual

IN-TRAC Clinical Research & Patient Care Core (CRPCC) ABSTRACT Tuberculosis (TB) is a leading infectious disease cause of death worldwide. In the US, TB incidence rates are historically low, but control remains challenging in certain populations, including the communities along the US border with Mexico. Thus, there is an urgent need for the next generation of TB researchers to have an understanding of the clinical and epidemiological aspects of TB research, as a foundation for their future leadership in the development of improved TB diagnostics, surveillance, treatments and vaccines. The Clinical Research & Patient Care Core (CRPCC) of the IN-TRAC will provide to New TB Investigators (NIs) and investigators new to the TB field, the infrastructure, resources and training in TB clinical research, and education on the challenges faced by clinicians in managing TB cases. Our training sites are strategically located in south Texas, a state adjacent to Mexico, which is the number one country of origin for foreign-born TB cases in the US. The TB clinical research site is led by Dr. Restrepo, an expert in TB field epidemiology and pathogenesis in TB patients with diabetes comorbidity or old age. Her field site is unique within the US due to its access to TB patients enrolled on the Mexican side of the Texas border. The TB patient care training will be in San Antonio, led by Drs. Armitige and Seaworth, an exemplary team of physicians who are affiliated with the only free-standing TB hospital in the US, the Texas Center for Infectious Diseases (TCID). In the same setting, there are also busy outpatient clinics: The San Antonio Metropolitan Health Department Chest Clinic, and a TB regional training and medical consultation Center of Excellence (The Heartland National TB Center; HNTBC). Our Aims are to: Aim 1. Execute a personalized training curriculum on TB clinical research studies. We have designed a hybrid (hands-on and virtual) training curriculum for IN-TRAC participants on all aspects of Clinical TB Research, including ethics, study design, field logistics, data and specimen management, specimen processing and data analysis plans and communications. Aim 2. Execute a personalized training curriculum on TB patient care. IN-TRAC participants will be educated on the complex set of decisions that physicians make, particularly during the management of difficult TB cases (e.g. with DR-TB, or with social problems such as homelessness), and who require specialized management and prolonged in-hospital stays. The mentoring team will meet with each IN-TRAC participant prior to their rotation to discuss customization of the core curriculum, including the development of a pilot project, depending on the IN-TRAC participant’s interest. IN-TRAC participants will provide a written and oral evaluation of their training experience.

IN-TRAC临床研究和患者护理核心（CRPCC）摘要 结核病（TB）是全球主要的传染病死亡原因。在美国，结核病发病率为 历史上较低，但在某些人群中控制仍然具有挑战性，包括美国沿着的社区 与墨西哥接壤。因此，迫切需要下一代结核病研究人员拥有一个 了解结核病研究的临床和流行病学方面，作为其未来的基础 在开发更好的结核病诊断、监测、治疗和疫苗方面发挥领导作用。临床 IN-TRAC的研究和患者护理核心（CRPCC）将向新的结核病研究者（NI）提供， 结核病领域的新研究人员、结核病临床研究的基础设施、资源和培训以及教育 关于临床医生在管理结核病病例方面所面临的挑战。我们的培训地点位于南 德克萨斯州毗邻墨西哥，是美国第一大外国出生结核病病例的来源国。 我们结核病临床研究中心由Restrepo博士领导，他是美国结核病现场流行病学和发病机理专家。 患有糖尿病合并症或老年的结核病患者。她的现场在美国是独一无二的，因为它可以接触到结核病 在德克萨斯州边境的墨西哥一侧登记的患者。结核病患者护理培训将在圣安东尼奥举行， 由Armitige和Seaworth博士领导，这是一个由医生组成的模范团队，他们隶属于唯一一个独立的 美国德克萨斯州传染病中心（Texas Center for Infectious Diseases，TCID）同样的布景里，也有忙碌忙碌的身影 门诊诊所：圣安东尼奥大都会卫生部胸部诊所，结核病区域培训和 卓越医疗咨询中心（中心地带国家结核病中心; HNTBC）。我们的目标是：目标 1.执行结核病临床研究的个性化培训课程。我们设计了一种混合动力车 为IN-TRAC参与者提供有关临床结核病研究各个方面的（实际操作和虚拟）培训课程， 包括伦理学、研究设计、现场后勤、数据和标本管理、标本处理和数据 分析计划和沟通。目标2.执行结核病患者护理的个性化培训课程。 IN-TRAC参与者将接受有关医生做出的一系列复杂决策的教育，特别是在 疑难结核病病例的管理（例如耐药结核病或无家可归等社会问题），以及 他们需要专门的管理和长期住院。 辅导小组将在每一个核心预算资源调拨目标参与者轮调之前与他们会面， 核心课程，包括根据核心预算资源调拨目标参与者的兴趣制定一个试点项目。 IN-TRAC参与者将对其培训经历提出书面和口头评价。