Metal free Arylation in Biological Systems

一种系统的催化方法正在出现，作为一个框架，生物技术工业中的所有分子(药物、农用化学品、商品、分子探针等)都将在该框架下合成。这种未来的合成将以联合和连贯的方式利用整个生物体(合成生物学)、生物催化和化学催化，从而在成本、环境足迹和合成效率方面显著简化合成路线。这将需要新的工作方式；拟议的多学科项目提供了化学、生物和分析科学方面的培训，这将为更多地以系统为主导的工业生物技术方法创造必要的工作环境。该项目建议将最先进的生物结合系统转化为生产生物技术的积木，在化学和生物学的界面上提供真正当代的博士培训体验。

A systems approach to catalysis is emerging as the framework under which all molecules (drugs, agrochemicals, commodities, molecular probes etc) in the biotechnology industry will be synthesised. This future synthesis will utilise whole organisms (synthetic biology), biocatalysis and chemo-catalysis in a joined-up and coherent fashion, such that synthetic routes are dramatically streamlined in terms of costs, environmental footprint and synthetic efficiency. This will require new ways of working; the proposed multi-disciplinary project offers training in chemistry, biology and analytical science that will produce the working environment necessary for a more systems-led approach to industrial biotechnology. The project proposes to translate state of the art bioconjugation systems in to produce biotechnology building blocks, providing a truly contemporary PhD training experience at the interface of chemistry and biology.