Training in the Genome Sciences and the Hemoglobinopathies

描述：请参阅说明。阐明应用程序的广泛、长期目标和具体目标，并参考与健康相关的 该项目(L.E，与该机构的主要业务相关)。简明扼要地描述实现这些目标的研究设计和方法。 你将用来追求这些目标的基本原理和技巧。 此外，用两三句简单明了的话描述这项研究与公共卫生的相关性。如果应用程序得到资助，则此 描述，按原样，将成为公共信息。因此，不包括专有/机密信息。请勿超出空格 但前提是。、？。.^_^__ 杜克大学-北卡罗来纳大学教堂山分校(UNC)培训的总体目标 基因组科学和血液病计划培训一批国内和 ‘外国博士后研究员将成为优秀的研究人员，研究基础和治疗 血红蛋白增多症。使用基因组和相关的大规模和高通量方法 基因组科学。每个受训者选择的重点领域是否是基因组学。蛋白质组学或 计算生物学和一个人未来的研究是否是基础，翻译！还是临床，每个人都会 期望对应用于正在进行的基因组科学有广泛和全面的理解 关于血红蛋白疾病的研究项目。实现这一目标的培训将通过以下方式实现：高级 课程；基因组学、蛋白质组学和计算实验室的广泛轮换；每周一次 涉及基因组科学研究人员的座谈会；在具有活跃计划的实验室进行研究 生物医学研究；以及通过培训拥有基因组专业知识的教师来共同指导 科学和血红蛋白疾病，以发展对多学科的充分认识 这一训练计划的性质。 培训计划将由杜克大学基因组科学研究所所长联合指导。 政策和杜克-北卡罗来纳大学综合镰刀细胞中心主任。杰出的研究员将是 从一大批申请者中确定了两所杜克大学现有的博士后培训机会 血液学、输血医学、医学基因组学、血管疾病和基因组学中的UNG 科学；从申请者到杜克大学和北卡罗来纳大学的个人导师；以及来自由 由坦桑尼亚和泰国的同事和合作者组成的国际顾问小组。研究 杜克大学和北卡罗来纳大学的25多名教职员工将提供机会，这些教职员工具有以下专业知识 基因组科学和血红蛋白疾病。 我们将培养一批致力于推动我们的发展的国内外同行 对血红蛋白病的认识和治疗。这一调查网络将构成 正在进行的一系列国际合作，以减轻这些疾病的痛苦和负担。 表演SLTE(S)(组织、城市、石板) 杜克大学，北卡罗来纳州达勒姆 北卡罗来纳大学，教堂山，北卡罗来纳州 PHS 398(未加工09/04)第2页表单页面a 03/03/06 11：40FAX@]004 Kirschstein-NRSA初始预算原则mfngrm晚宴。W)贾迪·亨廷顿F。 句点替代页(&lt；La8t|“”*？mldddte) 直通

DESCRIPTION: Seeinstructions. Stele the application's broad, long-term objectives andspecific aims, making reference to trie health relatednoss of the project (l.e,, relevanceto the mlaslon of the agency). Describe concisely the research design and methods for achieving these goals.Describe the rationale andtechniques youwill useto pursue these goals. in addition, In two or three sentences, describe In plain, lay language the relevance of this research to public health. If the application is funded, this description, as is, will become public Information. Therefore, do not Include proprietary/confidential Information. DO NOT EXCEEDTHE SPACE PROVIDED. , ¿ . . .¿ _^__ the overall goal of the Duke University - University of North Carolina at Chapel Hill (UNC) Training Program in the Genome Sciences and the HemogloblnopathiesIs to train a cohort of both domestic and 'foreign postdoctoralfellows to be outstanding investigators of the basis for and treatment of the herhoglobinbpathies. using genomlcs and related large-scale and high-throughput approaches in the genome sciences. Whether each trainee's chosen area of focus Is in genomics. proteomics or computational biology and whether one's future research is basic, translations! or clinical, each fellow will be expected to gain a broad and comprehensiveunderstandingof the genome sciences as applied to ongoing research projects In the hemoglobinopathies. Training towards this goal will be achievedthrough: advanced coursework; extensive rotations in genomics, proteomics, and computational laboratories; a weekly colloquium involving researchers in the genome sciences; researchin laboratories with active programs In herhbglbbihopathy research; and co-mentoring by training faculty with expertise both in the genome sciences and in the hemoglobinopathies in order to develop a full appreciation for the multidlsciplinary nature1of this training prograrn. The training programwill be directedjointly by the Director of the Duke Institute for Genome Sciences& Policy and by the Director of the Duke-UNC Comprehensive Sickle Cell Center. Outstandingfellows will be identified from among a strong pool of applicants to existing postdoctoral training opportunities at both Duke and UNG in hematology, transfusion medicine, medical genomics, vascular disease and the genome sciences; from applicantsto Individual mentorsat Duke and UNC; and from applicants identified by an international advisorygroup consisting of colleagues and collaboratorsin Tanzania and Thailand. Research opportunities will be providedby a group of more than 25 Duke and UNC faculty members with expertise in the genome sciences and in the hemoglobinopathies. We will develop a group of domestic andforeign colleagues who are dedicated to advance our understanding and treatment of the hemoglobinopathies. This network of investigators will form the basis for an ongoing series of internationalcollaborationsto reducethe pain and burden of these disorders. PERFORMANCE SlTE(S) (organization, city, slate) Duke Uhiversity, Durham, North Carolina University of North Carolina, Chapel Hill, North Carolina PHS 398 (Raw. 09/04) Page 2 Form Pagea 03/03/06 11:40FAX @]004 Kirschstein-NRSA Initial Budget PrincipalinmagMfngrm Dinner. W)jiardi HuntingtonF. Period Substitute Page <La8t| ""*¿mlddte) THROUGH