Pediatric Polysomnography

描述（由申请人提供）：20世纪50年代出现的多导睡眠图是一种记录和分析睡眠的客观手段，它极大地加速了对睡眠的科学描述的进展，包括建立年龄-性别规范。在20世纪80年代，多导睡眠描记术使阻塞性睡眠呼吸暂停的发现和描述成为可能。阻塞性睡眠呼吸暂停是一种相对常见的疾病，有高血压、中风、糖尿病、癫痫，可能还有阿尔茨海默病的一些变体，对清醒时的认知功能和情绪也有不利影响。在过去的二十年里，相对便宜的台式电脑与多导睡眠描记术的结合催生了数字/计算机多导睡眠描记术（cPSG）领域。虽然cPSG在数据显示和编辑的灵活性和易用性以及空间要求和数据存档成本方面比其模拟前身提供了无可争议的优势，但cPSG在30秒计算机监视器屏幕上提供了数据表示/分析和显示的准确性降低。提出的工作为多导睡眠描记法提供了第三种范式进展的可能性——一种最初设想的软件系统，它建立在过去十年计算机硬件和软件技术进步的基础上，能够准确地表示、显示、分析、生成报告和存档儿童（和成人）睡眠的核心动态睡眠波和波形。同时保持为儿童和成人睡眠提供传统计算“睡眠架构”宏观参数的能力。我们完成的第一阶段工作成功地进行了系统基础波形检测和分析工具的实验开发和验证，用于准确表示、显示和分析儿童睡眠的δ波。第二阶段的工作将把这一开发扩展到儿童睡眠的所有主要波和波形，另外还将开发一个工具，允许从多个硬件平台和多种数据格式访问PSG数据，以及一个功能强大但相对便宜的数据库管理模块，提供定制的数据存档。创新的系统开发将通过台架测试和睡眠实验室对其自动分析能力的验证研究进行验证。该系统的能力远远超过商用系统提供的能力，预示着巨大的商业潜力。

DESCRIPTION (provided by applicant): Polysomnography, the advent in the 1950s of an objective means of recording and analyzing sleep, greatly accelerated progress in the scientific description of sleep, including the establishment of age-sex norms. In the 1980s, polysomnography enabled the discovery and description of obstructive sleep apnea, a relatively common condition having co-morbidities such as hypertension, stroke, diabetes, epilepsy, and possibly some variants of Alzheimer's disease, as well as detrimental effects on waking cognitive function and mood. During the past two decades, the marriage of relatively inexpensive desktop computers to polysomnography has spawned the field of digital/computerized polysomnography (cPSG). While cPSG has offered indubitable advantages over its analog predecessor in terms of the flexibility and ease of data display and editing, as well as in space requirements and cost of data archival, cPSG provides a decreased accuracy of its data representation/analysis and display on the 30 second computer monitor screen. The proposed work offers the possibility of a third paradigmatic advance in polysomnography-an originally conceived software system that builds upon technological advances of the past decade in computer hardware and software, enabling accurate representation, display, analysis, report generation, and archival of the core dynamic sleep waves and waveforms of children's (and adults') sleep, while maintaining capability of providing traditionally computed "sleep architecture" macroparameters for pediatric and adult sleep. Our completed Phase I work successfully performed bench work development and validation of the system's foundational waveform detection and analysis tools for the accurate representation, display, and analysis of the delta waves of pediatric sleep. The Phase II work will extend this development to all of the primary waves and waveforms of pediatric sleep, additionally scaffolding the development to a tool permitting accessing of PSG data from multiple hardware platforms and in multiple data formats, and to a powerful but relatively inexpensive database management module offering customized data archival. The innovative system development will be validated by bench testing and by a sleep lab validation study of its automated analysis capability. The system's capabilities far exceed the capabilities offered by commercially available systems, auguring an enormous commercial potential.