Uganda HIV/TB COHRE Training Program

描述（由申请人提供）：尽管在过去10年里，乌干达的艾滋病毒血清患病率有所下降，但乌干达的艾滋病毒疫情远未得到控制。在艾滋病毒流行的情况下，结核病的发病率很高，死亡率很高。随着抗逆转录病毒疗法的出现，仅靠预防战略已不足以满足乌干达目前的需要。现在，将艾滋病毒领域的显著进展带给乌干达等发展中国家在道义上势在必行。重建乌干达公共卫生基础设施的一个关键步骤是，乌干达卫生部、国防部和马凯雷雷大学之间开展了独特的合作，成立了联合临床研究中心。联合儿童中心是一个完全致力于艾滋病毒的研究和保健机构，并在向非洲开放抗逆转录病毒治疗方面处于领先地位。多年来，JCRC与凯斯西储大学（CWRU）、国家结核病和麻风病控制规划（NTLP）、马凯雷雷大学和姆巴拉拉大学建立了强有力的合作关系。拟议的培训计划将以这些与控制艾滋病毒和结核病的共同使命的牢固关系为基础。这一培训方案的目标是扩大国家能力，通过临床、业务和卫生服务研究，应对乌干达不断演变的艾滋病毒和结核病流行带来的公共卫生和科学挑战。通过这一培训方案，乌干达将建立能力，将基础和临床研究成果转化为公共卫生政策和干预措施，并评估其有效性。该培训计划将以越来越多的艾滋病毒和结核病临床研究项目为基础，但将把这些研究的结果扩展到公共卫生和政策领域。这些目标将通过一个连贯的学位和非学位培训方案来实现，该方案将与乌干达艾滋病研究中心合作，加强乌干达开展与艾滋病毒和结核病有关的综合临床、业务和保健服务研究的能力。该项目的研究培训将与乌干达坎帕拉JCRC、美国CWRU、姆巴拉拉科技大学、NTLP、坎帕拉市议会、疾病预防控制中心、美国国际开发署和伊丽莎白格拉泽儿科基金会正在进行的研究和项目活动联系起来。

DESCRIPTION (provided by applicant): Although the seroprevalence of HIV has declined in Uganda over the past 10 years, the HIV epidemic in Uganda is far from controlled. In the face of the HIV epidemic, tuberculosis rates are high and associated with significant mortality. With the advent of antiretroviral therapy, prevention strategies alone are no longer sufficient to meet the current needs in Uganda. There is now a moral imperative to bring the remarkable advances in the field of HIV to developing countries like Uganda. One key step in the rebuilding of the Ugandan public health infrastructure resulted from a unique collaboration between the Ugandan Ministry of Health, the Ministry of Defense and Makerere University to form the Joint Clinical Research Center (JCRC). The JCRC is a research and health care facility devoted entirely to HIV and leads the way in opening Africa to antiretroviral therapy. Through the years, the JCRC has formed strong collaborations with Case Western Reserve University (CWRU), the National Tuberculosis and Leprosy Control Programme (NTLP), Makerere and Mbarara Universities. The proposed training program will build on these strong relationships with the common mission of controlling HIV and TB. The goals of this training program are to expand the national capacity to address the public health and scientific challenges of the evolving HIV and TB epidemic in Uganda through clinical, operational and health services research. Through this training program Uganda will build the capacity to translate basic and clinical research findings into public health policy and interventions, and to evaluate their effectiveness. The training program will build on a growing number of clinical research projects on HIV and TB, but will extend the findings of these studies to the public health and policy arena. The goals will be met through a coherent program of degree and non-degree training in collaboration with CWRU, that will strengthen the capacity in Uganda to conduct integrated clinical, operational and health services research related to HIV and TB. The research training in this program will be linked to the ongoing research and program activities at the JCRC in Kampala, Uganda, CWRU, in the US, Mbarara University of Sciences and Technology, NTLP, Kampala City Council, CDC, USAID and Elizabeth Glaser Pediatric Foundation.