Evaluation of Age-Related Eye Disease Study (AREDS) Clin

标准化的透镜摄影与照片的集中分级已被用于临床 白内障的临床试验和流行病学研究虽然摄影分级系统已经 虽然这些方法被证明是可靠的，但它们过于昂贵和复杂，无法在许多研究中使用。对于一些大型 研究，尤其是具有多个中心或透镜变化为次要的研究 考虑到这一点，具有一种简单的临床透镜分级系统将是有用的，该系统是可靠的， 可以在对检查员进行最少培训的情况下使用。几种临床透镜分级系统已经被 在专门的透镜研究人员手中开发并发现是可靠的，但该系统 其他眼科医生很难可靠地使用。 白内障相关眼病研究（AREDS）开发了一种简化的临床白内障 分级系统，以评估核，皮质和后囊下白内障的严重程度， 老年性白内障的三种主要类型该系统的设计需要最少的检查员 对已经熟练使用裂隙灯的人员进行培训。共有150名患有不同严重程度白内障的参与者，他们已经参加了其他NEI方案， 评估系统的可靠性。散瞳后，每名受试者将由2名检查员独立进行透镜分级。提供有效性信息 在临床分级中，将拍摄透镜照片并使用详细的AREDS进行分级 照片分级系统。这些数据将使我们能够评估（1） AREDS临床透镜分级系统和AREDS分级透镜摄影系统 （2）眼科医生对白内障严重程度评估的一致性 (with不同的亚专业）使用AREDS临床透镜分级方法。所有患者均已招募，数据分析正在进行中。

Standardized lens photography with centralized grading of photographs has been used in clinical trials and epidemiologic studies of cataract. While photographic grading systems have been shown to be reliable, they are too expensive and complex to use in many studies. For some large studies, especially those with many centers or those in which lens changes are of secondary concern, it would be useful to have a simple clinical lens grading system that is reliable and that can be used with minimal training of examiners. Several clinical lens grading systems have been developed and found to be reliable in the hands of dedicated lens researchers, but the systems have been difficult for other ophthalmologists to use reliably. The Age-Related Eye Disease Study (AREDS) has developed a simplified clinical cataract grading system to assess the severity of nuclear, cortical and posterior subcapsular cataracts, the 3 main types of age-related cataract. The system is designed to require minimal examiner training for persons already proficient in the use of the slit lamp. A total of 150 participants with cataracts of varying severity, who are already participating in other NEI protocols, will be recruited to evaluate the reliability of the system. After being dilated, each participant will have a lens grading performed independently by 2 examiners. To provide information on the validity of the clinical gradings, lens photographs will be taken and graded using the detailed AREDS system for grading photographs. The data will allow us to evaluate (1) the agreement between the AREDS clinical lens grading system and the AREDS photographic system of grading lens opacities, and (2) the agreement on assessment of cataract severity among ophthalmologists (with varying subspecialty) using the AREDS clinical lens grading method. All patients have been recruited and the data analyses are underway.