FIND (Familial Investigation of Nephropathy in Diabetes)

肾病和糖尿病家族调查(FIND)旨在确定糖尿病肾病的致病基因及其与肾病的关联关系。这项糖尿病视网膜病变研究的目标是评估糖尿病肾病和糖尿病视网膜病变之间是否存在遗传联系。是否存在易患糖尿病肾病和视网膜病变的遗传因素？是否有遗传因素对视网膜病变或肾病有独特的易感性？第二个目标是对更严重的糖尿病视网膜病变进行基因连锁研究。 NIDDK赞助的FIND研究将招募糖尿病肾病先证者及其家庭成员。大多数先证者会受到不同程度的糖尿病视网膜病变的影响。FIND是一个多中心联盟，由八(8)个参与研究人员中心(PIC)和一个基因分析和数据协调中心(GADCC)组成，旨在研究糖尿病肾病的遗传学。七(7)张照片、中央眼底照片阅读中心和GADCC参与了视网膜病变研究。该财团的任务是获得一组具有良好特征的糖尿病肾病家系，建立一个安全的主Find数据库，并进行基因组扫描，以确定与糖尿病肾病相关的染色体区域。分析方法将包括)受影响同胞对(ASP)、不一致同胞对(DSP)、受影响亲属对(ARP)和不一致亲属对(DRP)连锁分析。患有糖尿病的先证者和家庭成员将接受眼科检查和眼底摄影。受影响的概率、受影响的兄弟姐妹对/不和谐的兄弟姐妹对和受影响的亲属对/不和谐的亲属对将参与视网膜病变研究。这项研究已经完成了患者的招募，分析工作正在进行中。

The Family Investigation of Nephropathy and Diabetes (FIND) is designed to identify genes responsible for diabetic nephropathy and their linkage relationships, if any, to nephropathy. The goal of this study of diabetic retinopathy in this population is to evaluate whether there is a genetic link between diabetic nephropathy and diabetic retinopathy. Are there genetic factors that predispose to both diabetic nephropathy and retinopathy? Are there genetic factors that predispose uniquely to either retinopathy or nephropathy respectively? A secondary goal is to perform a genetic linkage study of more severe diabetic retinopathy. The NIDDK-sponsored FIND study will recruit probands with diabetic nephropathy and their family members. The majority of the probands will be affected with diabetic retinopathy of various degrees of severity. FIND is a multi-center consortium, comprising eight (8) Participating Investigator Centers (PICs) and a Genetic Analysis and Data Coordinating Center (GADCC), established to study the genetics of Diabetic Nephropathy. Seven (7) of the PICs, a central fundus photograph reading center, and the GADCC are participating in the retinopathy study. The charge of the consortium is to acquire sets of families with well-characterized diabetic nephropathy, establish a secure master FIND database, and perform a genome scan to identify chromosomal regions linked with diabetic nephropathy. Analytic methods will include a) affected sibling pair (ASP), discordant sibling pair (DSP), affected relative pair (ARP), and discordant relative pair (DRP) linkage analyses. Probands and family members who are diabetic will undergo an eye examination and fundus photography. The affected probaland, the affected sibling pair/discordant sibling pair and affected relative pair/discordant relative pair will participate in the retinopathy study. This study has completed recruitment of patients and the analyses are underway.