From Clinic-Bench&Back:Clinical Biodetective Train*(RMI)

这个新的博士前培训计划的目标是培养独立的跨学科科学家，他们将开发新的方法来检测疾病状态、健康状况和治疗标记。虽然传统的生物医学研究方法已经带来了许多重大突破，但目前的提案将填补这一方法的空白。传统的方法是以基础科学为中心的；我们的方法是以临床为中心的。我们将培养基础科学家，他们将能够熟练地理解临床需求，能够设计和制造设备、方法和化学品来满足这一需求，并且能够在活组织中测试这些设备、方法和化学品。该建议中的两个主要创新培训策略是与临床医生密切合作（例如，家庭实践）

The goal of this new predoctoral training program is to produce independent interdisciplinary scientists who will develop novel methods for the detection of disease states, markers of good health, and therapeutic markers. While the traditional biomedical research approach has led to many significant breakthroughs, there is a gap in this approach that the current proposal will fill. The traditional approach is basic-science centered; our approach is clinically-centered. We will train basic scientists who will be skilled in understanding clinical needs, who can design and build devices, approaches, and chemicals to fill this need, and who will be able to test these devices, approaches, and chemicals in living tissues. The two major innovative training strategies in this proposal are to work closely with clinicians (e.g., family practice physicians, nurses, internal medicine clinicians and clinical scientists) to identify clinical problems of relevance and significance to them and to have dual basic science mentors: in the invention mentor's lab the device or approach will be developed or built (e.g., Chemistry, Engineering, Math or Physics mentor) and in the life science mentor's lab the device or approach will be analyzed in a living system (e.g., Biochemistry, Medical Pharmacology and Physiology, or Veterinary Biomedical Sciences mentor). This approach will be interdisciplinary AND will be focused on solving significant clinical problems. It develops basic scientists who start with the clinical need first. This approach complements the existing traditional "bench to bedside translational research" training approach but takes it full circle. A major innovation is that we will also consider devices and approaches that will allow us to move from bench to community (i.e., approaches that can be used in family practice settings, by nurses and nurse practitioners, and by patients for selfmonitoring) in situations where the patient and clinician are not necessarily in a hospital setting.