Moffitt Aging and Cancer Program Development

产品说明：（申请人的描述）这个规划和发展（P20）补助金申请，提交了对RFA CA-030504的回应，寻求资金，以发展一个老龄化和癌症研究计划在H。Lee Moffitt癌症中心和研究所，一个NCI指定的综合癌症中心。 莫菲特癌症中心非常适合发展这样一个项目，其基础是：1）它位于一个有大量老年人的地理区域; 2）在该中心接受治疗的老年人数量相对较多; 3）该中心多年来一直存在一个老年人肿瘤临床项目，为发展老龄化和癌症研究合作提供了初步机会; 4）众多癌症中心成员的存在感兴趣于将他们的关注点扩展到包括与衰老相关的问题;以及5）南佛罗里达大学（所有癌症中心成员都在那里担任教职）的众多衰老研究人员的存在感兴趣于将他们的关注点扩展到包括与癌症相关的问题。该奖项提供的资金将用于开发与最近NINNCI研讨会报告中确定的五个老龄化和癌症主题相关的研究：治疗效果和耐受性，合并症和癌症的影响，心理社会问题和医疗影响，姑息治疗，临终关怀和疼痛缓解，以及衰老和癌症的生物学。 为此，资金将用于支持这些领域中有前途的试点研究，以及旨在促进老龄化和癌症研究人员之间更多合作的各种规划和教育活动。 资金还将用于聘请基础科学和临床研究方面的新教师，他们的背景和专业知识将被确定为有希望进行合作的领域联系起来。 此外，资金将用于建立一个新的健康成果测量共享资源，该资源可能会被许多进行老龄化和癌症研究的受资助研究人员使用，并加强现有的共享资源，为临床试验的进行提供生物统计支持和支持。申请文件中包含的承诺信表明了莫菲特癌症中心高层领导对这一努力的大力支持。 与RFA的目标相一致，获得该奖项预计将导致老龄化和癌症研究计划的发展，该计划将值得纳入莫菲特癌症中心未来的癌症中心支持补助金申请。

DESCRIPTION: (Applicant's Description) This Planning and Development (P20) Grant application, submitted in response to RFA CA-030504, seeks funding to develop an Aging and Cancer Research Program at the H. Lee Moffitt Cancer Center and Research Institute, an NCI-designated Comprehensive Cancer Center. The Moffitt Cancer Center is ideally suited to develop such a program based on: 1) its location in a geographic region with a large population of older adults; 2) the relatively large number of older adults receiving treatment at the center; 3) the existence for many years of a Senior Adult Oncology Clinical Program at the center that has provided initial opportunities to develop aging and cancer research collaborations; 4) the presence of numerous cancer center members interested in expanding their focus to include issues related to aging; and 5) the presence of numerous aging researchers at the University of South Florida (where all cancer center members hold their faculty appointments) interested in expanding their focus to include issues related to cancer. Funds provided by this award would be used to develop research related to five aging and cancer themes identified in a recent NINNCI Workshop Report: Treatment Efficacy and Tolerance, Effects of Comorbidity and Cancer, Psychosocial Issues and Medical Effects, Palliative Care, End-of-Life Care, and Pain Relief, and the Biology of Aging and Cancer. Toward this end, funds would be used to support promising pilot research in each of these areas as well as a variety of planning and educational activities designed to foster additional collaborations among aging and cancer researchers. Funds also would be used to hire new faculty in basic science and clinical research whose backgrounds and expertise bridge areas identified as promising for collaboration. In addition, funds would be used to establish a new shared resource in Health Outcomes Measurement that is likely to be used by numerous funded investigators conducting aging and cancer research, and to enhance existing shared resources providing biostatistical support and support for the conduct of clinical trials. Letters of commitment included in the application document the strong support of the senior leadership of the Moffitt Cancer Center for this effort. Consistent with the goals of the RFA, receipt of this award is expected to lead to the development of an Aging and Cancer Research Program that will merit incorporation into future Cancer Center Support Grant applications by the Moffitt Cancer Center.