Multi-spectral single-scan digital lung imaging system

描述（由申请人提供）：本研究项目的长期目标是开发多光谱单扫描肺部成像系统。我们的主要假设是，通过患者的每个路径（线积分）的多光谱投影数据的基本上同时和共配准采集将有助于肺部疾病的检测和表征。该项目的核心是开发一种快速、低噪声的全帧采样窄孔径CMOS探测器，可以在感兴趣的身体后面进行扫描。与每个探测器行前进和全帧采样同步，X射线光谱以这样的方式变化（通过技术、过滤和潜在的X射线阳极跟踪和靶材料选择），即通过待成像和分析的身体的每个线积分以多种光谱进行采样。结果，在解剖结构的单次扫描中，在单独的谱条件下采集多个基本上同时间和共配准的投影图像。然后将这些图像数据分解到多个基函数上（然后可以单独显示或以各种加权组合显示）。在本申请的第一阶段，我们将重点关注同时间和共配准多光谱胸部成像的可行性证明。I期研究的具体目标是：（1）证实肺癌筛查的方法潜力;（2）证明系统的可行性。

DESCRIPTION (provided by applicant): The long-term objective of this research project is to develop a multi-spectral single-scan lung imaging system. Our primary hypothesis is that the essentially simultaneous and co-registered acquisition of multi-spectral projection data for each path (line-integral) through the patient will help in the detection and characterization of lung diseases. At the heart of the project will be the development of a fast and low-noise full-frame sampling narrow-aperture CMOS detector that can be scanned behind the body of interest. In synchronicity with each detector-row advance and full frame sampling, the x-ray spectra are varied (via techniques, filtration, and potentially x-ray anode track and target material selection) in such a way that each line-integral through the body to be imaged and analyzed is sampled at a multiplicity of spectra. As a result, in a single scan of the anatomy a multiplicity of essentially co-temporal and co-registered projection images are acquired under separate spectral conditions. These image data are then decomposed onto a multiplicity of basis functions (which may then be displayed separately or in various weighted combinations). In Phase I of this application we will focus on the proof of feasibility for co-temporal and co-registered multi-spectral chest imaging. The Specific Aims for Phase I research are to: (1) Substantiate the approach potential for lung cancer screening; (2) Demonstrate system feasibility.