Hemodynamic Assessment of Renal Artery Disease

描述（由申请人提供）：本研究的总体目标是开发一种诊断方法，用于预测肾动脉粥样硬化狭窄的治疗是否能在控制高血压或维持肾功能方面提供足够的获益，以抵消治疗风险。肾动脉狭窄是比较常见的，但先前的研究表明，20至40%的患者显示很少或没有从血管成形术或支架植入术中获益。由于治疗具有重大风险，因此识别无法从治疗中获益的患者（以及相反，指示最有可能获得积极结局的患者）的能力是肾血管疾病管理的重要需求。本研究的目的是开发和评估狭窄的血流动力学意义的无创评估方法，先前的工作表明这与治疗结果直接相关。在拟议项目中，将为这一评价制定两种备选的基于模型的方法。将构建并测试脉动流体模，以提供用于模型开发和评估的解剖和流量/压力数据。

DESCRIPTION (provided by applicant): The overall goal of this research is the development of a diagnostic methodology for predicting whether treatment of atherosclerotic stenoses in the renal artery will provide sufficient benefit in controlling hypertension or maintaining renal function to offset the risks of the treatment. Stenoses in the renal artery are comparatively common, yet prior studies have shown that 20 to 40% of patients show little or no benefit from angioplasty or stenting. Since the treatment carries significant risk, the ability to identify patients who will not benefit from treatment (and, conversely, to indicate those patients who will be most likely to have positive outcomes) is an important need in management of renovascular disease. The objective of the research is to develop and evaluate methodologies for noninvasive evaluation of the hemodynamic significance of the stenosis, which prior work indicates is directly related to the outcome of treatment. Two alternative model-based approaches for this evaluation will be developed in the proposed project. A pulsatile flow phantom will be constructed and tested to provide anatomic and flow/pressure data for model development and assessment.