KURU EXPERIMENTS TRIGGERED THE EMERGENCE OF PATHOGENIC SIVMAC

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们已经确定了三条证据线，表明艾滋病动物模型研究中使用的致病性SIVmac菌株很可能起源于20世纪70年代在美国进行的库鲁病实验。具体而言，我们发现：（1）涉及将白眉猴脑组织颅内传代至猕猴和SIVmac出现的实验的时间和地点有很强的联系。(2)库鲁病研究组内SIVmac毒株簇的显著关联。以及，（3）库鲁病实验中使用的特定猕猴中的血清转化的确认。因此，这是合理的，高度侵入性的实验操作，而不是偶然的接触，无意中引起了高致病性SIV分离，从20世纪80年代到现在使用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have identified three lines of evidence which show that the pathogenic SIVmac strains used in AIDS animal model studies most likely originated as a result of kuru experiments conducted in the US in the 1970s. Specifically we have found: (1) A strong link in the time and location of experiments involving intracranial passaging of sooty mangabey brain tissue to macaques and SIVmac emergence. (2) A significant association of clusters of SIVmac strains within kuru study groups. And, (3) Confirmation of seroconversion in the specific macaques used in the kuru experiments. Therefore, it is plausible that highly invasive experimental manipulations, and not casual contact, inadvertently gave rise to a highly pathogenic SIV isolate, used from the 1980¿s to the present time.