ENDOMETRIAL CYCLES IN VERVET MONKEYS (CERCOPITHECUS AETHIOPS)

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。旧大陆的非人类灵长类动物，尤其是猕猴，长期以来一直是子宫内膜激素作用研究的实验动物模型。猕猴越来越难以获得，因此评估其他灵长类动物模型用于生殖道研究是很重要的。非洲绿猴是一种非人类的经期灵长类动物，其月经周期与女性相似。Vervets在生殖研究中的潜在用途之前已经被探索过。这些研究表明，这个物种的月经非常轻，需要每天用阴道拭子检测月经。该物种月经减少的生理机制尚未被探索。因此，我们的目的是评估雌二醇（E2）和孕酮(P)对该物种月经调节的循环作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Old world nonhuman primates, especially macaques, have long been the experimental animal model of choice for studies of hormone action in the endometrium. Macaques are becoming increasingly difficult to obtain and it is important to assess other primate animal models for studies on the reproductive tract. The African green monkey or Vervet is a menstruating nonhuman primate with menstrual cycles of similar duration to those of women. The potential use of Vervets for studies in reproduction has been explored previously. Those studies revealed that menstruation is very light in this species and that daily testing by vaginal swab is required in order to detect menses. The physiological mechanism underlying the attenuated menstruation in this species has not been previously explored. Therefore, our goal was to assess the cyclic effects of estradiol (E2) and progesterone (P) on the regulation of menstruation this species.