20 YEAR CHANGES IN FITNESS & CARDIOVASCULAR DISEASE RISK

尽管与年龄相关的有氧能力下降是有充分证据证明的，但体力活动、体脂和 关于变化率的遗传变异还不是很清楚。此外，人们对生物多样性的变化率如何 成年早期和中期的有氧能力影响心血管疾病危险因素的发展 亚临床和临床心血管疾病(CVD)相关终点的发生率。我们建议解决这些问题 在20年CARDIA(冠状动脉风险发展)的同时进行辅助研究的问题 (青少年)考试，计划于2005年6月开始。我们预料到 在最初的非裔美国人和白人男性队列中，大约3650人(75%)幸存下来， 女性将返回参加20年级考试，届时她们的年龄将在38-50岁之间。建议的总体目标是 辅助研究是为了了解身体素质、身体活动、身体之间复杂的、纵向的关系 体重、组成和脂肪分布，遗传因素及其独立或交互影响 肥胖、代谢综合征和亚临床心血管疾病的发展。为达致这个目标，我们建议 对所有第20年的CARDIA参与者进行衡量： 有氧能力，通过症状受限的分级运动跑步机测试，使用与使用的相同方案 在CARDIA的0年级和7年级考试中； 身体成分和脂肪分布，使用全身双能X射线吸收(DEXA)扫描； ？体力活动，使用7天的加速度计记录；以及 选定的与心肺功能相关的候选基因中的D NA序列变异， 代谢综合症，以及对常规运动的反应，使用储存的DNA。 这项辅助研究的数据将与CARDIA核心检查数据相结合，以实现以下目标： 检查身体质量和成分的贡献，脂肪分布，客观测量体力活动 以及20岁有氧能力和与年龄相关的有氧能力下降的特定遗传多态 从青年到中年的20年时间内的能力，按种族和性别分层。 有氧能力对心血管疾病危险因素变化影响的纵向研究 心血管疾病相关终点的发生率(如高血压、代谢综合征、亚临床疾病[如冠状动脉疾病 动脉钙])。 这项研究的数据应该提供信息，帮助我们更深入地了解 心肺功能、身体成分和心血管疾病相关的危险因素和终点，并可能为 我对健身在心血管健康中的作用提出了更广泛的循证建议。 Performmanceite(S)(组织、市、州) 凯撒基金会研究所，研究部，加利福尼亚州奥克兰 阿拉巴马大学，亚利桑那州伯明翰 西北大学，伊利诺伊州芝加哥 德克萨斯大学休斯顿健康科学分校，德克萨斯州休斯顿 明尼苏达大学，明尼阿波利斯 关键人员。请参阅说明。根据需要使用续页，以如下所示的格式提供所需信息。 从首席调查员开始。按字母顺序列出所有其他关键人员，姓氏在前。 命名项目中的组织角色 斯蒂芬·西德尼医学博士研究部首席研究员 波文克尔，埃里克，德克萨斯大学博士，遗传学中心联合研究员 卡内森，梅赛德斯，西北大学博士，田野中心联合研究员 雅各布斯，David R.，Jr，明尼苏达大学博士，菲尔德中心联合研究员 刘易斯，科拉，医学博士，阿拉巴马MSPH大学，田野中心联合调查员 查尔斯·奎森伯里，研究生物统计学家博士 Sternfeld，Barbara，博士部研究联合调查员 威廉姆斯，O.Dale，公共卫生硕士，阿拉巴马大学博士，协调中心联合研究员 DISCLO-？R#-P#_RMI_ION_T_T#_m__NT_Annic._HLP.仅TN_BIR/RTTR RP_in.qtruc.ti(_n_[_YE_F“-i否 PHS 398(05/01版)第2页__表第2页。 首席研究员/项目主任(最后、第一、中间)：Sidney，Stephen，MD 研究补助金 目录 PA_Numbem 主页........................................................................................................................1 描述，

Although an age-related decline in aerobic capacity is well documented, the impact of physical activity, body fat, and genetic variation on the rate of change is not well understood. In addition, little is known about how rate of change in aerobic capacity during early and middle adulthood affects the development of cardiovascular disease risk factors or the incidence of subclinical and clinical cardiovascular disease (CVD) related end-points. We propose to address these issues by conducting an ancillary study in conjunction with the Year 20 CARDIA (Coronary Artery Risk Development in Young Adults) examination, which is scheduled to take place beginning in June, 2005. We anticipate that approximately 3,650 (75%) of the surviving members of the initial cohort of African American and white men and women will return for the Year 20 exam, at which point they will be 38-50 years old. The overall goal of the proposed ancillary study is to understand the complex, longitudinal relations between physical fitness, physical activity, body mass and composition and fat distribution, and genetic factors and their independent or interactive effects on the development of obesity, the metabolic syndrome, and sub-clinical CVD. To accomplish this goal, we propose to measure, on all Year 20 CARDIA participants: ¿ Aerobic capacity, by means of a symptom-limited graded exercise treadmill test, using the same protocol as that used in CARDIA at the Year 0 and Year 7 exams; ¿ Body composition and fat distribution, using a whole body dual energy x-ray absorptiometery (DEXA) scan; ¿ Physical activity, using 7 days of accelerometer recordings; and ¿ D NA sequence variants in selected candidate genes associated with cardiorespiratory fitness, components of the metabolic syndrome, and response to regular exercise, using stored DNA. Data from this ancillary study will be combined with core CARDIA examination data to address the following aims: ¿ E xamination of the contribution of body mass and composition, fat distribution, objectively measured physical activity and specific genetic polymorphisms to the variance in Year 20 aerobic capacity and in age-related decline in aerobic capacity over a 20-year time period from young adulthood to mid-life, stratifying by race and gender. ¿ Longitudinal examination of the effect of aerobic capacity on changes in cardiovascular disease risk factors and on the incidence of CVD-related endpoints (e.g. hypertension, metabolic syndrome, subclinical disease [e.g. coronary artery calcium]). Data from this study should provide information that will help us more deeply understand the interrelationships of cardiorespiratory fitness, body composition, and CVD-related risk factors and endpoints, and may provide the basis for I more extensive evidence-based recommendations on the role of fitness in cardiovascular health. PERFORMANCESITE(S) (organization, city, state) Kaiser Foundation Research Institute, Division of Research, Oakland, CA University of Alabama, Birmingham, AL Northwestern University, Chicago, IL University of Texas, Houston Health Sciences, Houston, TX University of Minnesota, Minneapolis, MN KEY PERSONNEL. See instructions.Use continuation pages as needed to provide the required informationintheformat shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Role on Project Sidney, Stephen, MD Division of Research Principal Investigator Boerwinkle, Eric, PhD University of Texas, Genetics Center Co-Investigator Carnethon, Mercedes, PhD Northwestern University, Field Center Co-Investigator Jacobs, David R., Jr, PhD University of Minnesota, Field Center Co-Investigator Lewis, Cora, MD, MSPH University of Alabama, Field Center Co-lnvestigator Quesenberry, Charles, Jr., PhD Division of Research Biostatistician Sternfeld, Barbara, PhD Division of Research Co-Investigator Williams, O. Dale, MPH, PhD University of Alabama, Coordinating Center Co-Investigator Disclo-¿.r#- P#_rmi___¿ion _t_t#_m__nt_ Annlic._hlp. tn _BIR/RTTR Only Rp._ in.qtruc.ti(_n_ [_ Ye_ F"-I No ¿ PHS 398 (Rev. 05/01) Page 2__ Form Page 2. Principal Investigator/Program Director (Last, first, middle): Sidney, Stephen, MD RESEARCH GRANT TABLE OF CONTENTS Pa_Numbem Face Page .................................................................................................................................................. 1 Description,