Animal Resource Improvement: YNPRC

描述（由申请人提供）：尽管在过去十年中取得了重大的科学进步，导致了治疗的改进和疫苗的前景，但艾滋病仍然是世界范围内的主要医学问题，每年有数百万人新感染和死亡。如果我们要成功地遏制并消除这一全球祸害，就必须继续在艾滋病研究方面取得进展。非人类灵长类动物模型的可用性是进行基础研究和临床前测试的关键要求，这些研究和测试是开发更好的治疗方法和疫苗所必需的。在NIH/NCRR的支持下，耶基斯NPRC多年来在艾滋病动物模型研究中发挥了重要作用-为这项工作分配了大量资源。艾滋病相关研究项目继续在YNPRC增加，主要由NIH资助。近年来，该中心经历了其研究计划和研究支持活动的范围加速增长，因为与非人灵长类动物模型的工作在许多领域变得越来越重要。因此，对支持对国家卫生需求至关重要的研究所需的基础设施的需求在耶基斯和全国都有所增加。该提案要求提供资金，将现有的传统灵长类动物饲养设施改造为BSL-2+灵长类动物饲养设施，以适合饲养分配给艾滋病相关研究方案的猴子。该设施的设计将遵循CDC-NIH《微生物和生物医学实验室生物安全手册》（第4版，1999年5月）中的建议。拟议的改造将为192只动物提供BSL-2+住房，比目前的容量增加66%。所要求的改善将为我们提供急需的额外住房，专门用于艾滋病研究，这将扩大我们与艾滋病有关的研究的范围和速度。

DESCRIPTION (provided by applicant): Despite significant scientific advances in the past decade leading to improved treatments and the prospect of a vaccine, AIDS continues to be a major medical problem world-wide, with new infections and deaths in the millions annually. Progress in AIDS research must continue if we are to be successful in containing, then eliminating, this global scourge. The availability of non-human primate models is a critical requirement to conduct the basic research and pre-clinical testing required to develop better treatments and vaccines. The NIH/NCRR supported Yerkes NPRC has played a significant role in AIDS animal model studies for some years - allocating substantial resources to this effort. AIDS related research projects continue to increase at the YNPRC funded largely by the NIH. In recent years, the Center has experienced accelerated growth in the scope of its research programs and research-support activities, as work with nonhuman primate models has become increasingly important in a number of realms. Consequently, the demand for infrastructure needed to support research vital to national health needs has increased both at Yerkes and nationally. This proposal requests funds to renovate an existing conventional primate housing facility into a BSL-2+ Primate Housing Facility suitable for holding monkeys assigned to AIDS-related research protocols. The design of the facility will follow the recommendations in the CDC-NIH Biosafety in Microbiological and Biomedical Laboratories Manual, 4th edition, May 1999. The proposed renovation will provide BSL-2+ housing for up 192 animals, an increase of 66% over current capacity. The requested improvements will provide us with critically needed additional housing dedicated for AIDS studies, which will augment both the scope and pace of our AIDS-related research.