INTEGRATIVE PROGRAM IN CNS PATHOPHYSIOLOGY RESEARCH

这是对机构发展奖(IDEA)的申请，目的是在新墨西哥大学(UNM)建立生物医学研究卓越中心(COBRE)，以开展我们的中枢神经系统损伤和病理生理学研究，采用以神经成像为重点的综合方法。其中一个目标是加强我们现有的独特的神经成像设施，使它们成为一个将功能神经成像技术应用于大脑研究的最先进的中心。在过去的十年里，UNM在神经成像领域发展了一个独特的利基市场，在包括脑磁图(MEG)、磁共振波谱(MRS)和最佳成像在内的多个领域拥有优势。我们还在建造电子顺磁共振(EPR)设备，用于体内制剂中自由基的非侵入性测量。为科布雷中心核心所需的四件主要设备将大大加强我们的中心，使我们能够在国家一级完成神经成像应用的各个领域。这包括升级用于动物研究的现有4.7T磁共振扫描仪和在体EPR光谱仪，以及用于使用体外和体内准备进行细胞最佳成像研究的光电二极管阵列和双光子激光扫描显微镜。我们的第二个目标是利用这种研究环境来提高我们教职员工的研究效率和质量，特别是初级教职员工，这样我们就可以增加定期个人NIH补助金(R01)级别的资助研究人员的数量。在新墨西哥州大学，有一批成功的高级调查人员，他们拥有活跃的国家卫生研究院定期个人补助金(RO1)。在UNM，有一组在中枢神经系统损伤和病理生理学领域拥有活跃RO1级资金的高级研究人员，他们专注于神经成像，他们可以建立一个合作研究团队，为促进教师发展创造一个令人兴奋和刺激的环境。在过去的十年里，我们机构活跃的调查人员数量的增加使Cobre成为教师发展的理想工具。我们已经确定了四名在中枢神经系统损伤和病理生理学领域工作的有前途的初级教员，他们可以通过这项想法拨款直接帮助他们成为R01级别的独立科学家。科布雷主任和高级调查员我们的团队将担任导师。这些有指导的研究人员提出的研究是多学科的和综合的，旨在对每种类型的病理生理学产生有用的系统的纵向特征，并对脑损伤和恢复的可能机制提供新的见解。为了帮助创造一个激励的研究环境，我们建议发起一个关于神经病理生理学的正式研讨会系列，每年组织一次关于及时主题的小型研讨会，并管理一个访问科学家计划。我们还成立了一个由本领域杰出科学家组成的国家咨询委员会，他们可以指导我们的COBRE的发展，初级教员在他们的科学工作中的进展将根据我们的导师计划进行监督。

This is an application for the Institutional Development Award (IdeA) to establish a Center for Biomedical Research Excellence (COBRE) at the University of New Mexico (UNM) for carrying our research in CNS injury and pathophysiology using an integrative approach with a neuroimaging focus. One goal is to strengthen our existing unique neuroimaging facilities so that they become integrated into a state-of-the- art Center for applying functional neuroimaging techniques in brain research. UNM has developed a unique niche in neuroimaging over the past ten years with strengths in a number of areas including Magnetoencephalography (MEG), Magnetic Resonance Spectroscopy (MRS), and Optimal Imaging. We are also in the process of constructing an Electron Paramagnetic Resonance (EPR) facility for non-invasive measurements of free radicals in in vivo preparations. Four pieces of major equipment requested for the core of this COBRE would substantially strengthen our Center, enabling us to complete at the national level in various areas of neuroimaging applications. This includes the upgrades of an existing 4.7T MR scanner and in vivo EPR spectrometer for animal studies, and a photodiode array and a two-photon laser scanning microscope for cellular optimal imaging studies using in vitro and in vivo preparations. Our second goal is to utilize this research environment for increasing the productivity and quality of research of our faculty, especially the junior faculty members, so that we can increase the number of funded investigators at the regular individual NIH grant (R01) level. At UNM there is a group of successful senior investigators with active regular individual NIH grant (RO1) level. At UNM there is a group of senior investigators with active RO1-level funding in the area of CNS injury and pathophysiology with a neuroimaging focus who can establish a collaborative research team that can service to create an exciting and stimulating environment for fostering faculty development. The increase in the number of active investigators at our institution over the past decade makes the COBRE an ideal vehicle for faculty development. We have identified four promising junior faculty members working in the area of CNS injury and pathophysiology who can be directly helped with support from this IdeA grant to become independent scientists from R01- level funding. The COBRE Director and the senior investigator our team will serve as the mentors. The proposed research by these mentored investigators is multi-disciplinary and integrative, designed to produce a useful systematic longitudinal characterization of each type of pathophysiology and to provide new insights into the possible mechanisms of brain injury and recovery. To help create a stimulating research milieu, we propose to initiate a formal seminar series on neuro- pathophysiology, to annually organize a mini-symposium on timely thematic topics, and to administer a visiting scientist program. We have also formed a national advisory committee consisting of prominent scientists in our field who can guide us in the development of our COBRE, The progress of the junior faculty members in their scientific work will be monitored according to our mentorship program.