Theoretical Population Genetics

描述（由申请人提供）：这个修订后的项目是关于开发新的统计方法的人口遗传数据。注意力将集中在三个主要领域：人口结构的表征，内和之间的遗传标记和沿着单倍型的关联模式的表征，以及两个以上的等位基因集的身份地位的表征。理论的发展至少部分是为了满足目前人类和其他物种的大规模SNP调查的需要。 具体的主题包括确定人口结构的具体措施和比较标记和基于特征的人口结构估计的抽样特性。将进行比较，目前的方法定义单倍型块，并考虑替代方法的基础上的多样性或偶然表和回归分析的一个标记与随后的标记单倍型。将开发用于推断一个基因座上两个以上等位基因之间或多个基因座上单个等位基因之间的关联的方法。

DESCRIPTION (provided by applicant): This revised project is concerned with developing new statistical methodology for population genetic data. Attention will be focused on three main areas: the characterization of population structure, the characterization of the association patterns within and between genetic markers and along haplotypes, and the characterization of the identity status of sets of more than two alleles. Theory will be developed at least in part in response to the needs of current large-scale SNP surveys of humans and other species. Specific topics include determining the sampling properties of population-specific measures of population structure and the comparison of marker- and trait-based estimates of population structure. A comparison will be conducted of current methods for defining haplotype blocks, and consideration of alternative methods based on diversity or on contingency-table and regression analyses of one marker versus haplotypes of subsequent markers. The means for drawing inferences about associations among more than two alleles at one locus, or among single alleles taken from multiple loci will be developed.