COBRE: UNE MED CTR: P1: ROLE OF DESMOSOMES IN ORAL SQUAMOUS CELL CARCINOMA

描述（由申请人提供）： 这个COBRE申请建议建立一个细胞信号中心，这将增加和加强内布拉斯加州牙科学校的研究能力。该中心将包括来自内布拉斯加州附近三所研究型大学的科学家：内布拉斯加大学医学中心、内布拉斯加大学林肯分校和克雷顿大学。林肯。该中心的目标是：1）扩大目前对细胞信号传导的关注，重点关注其在肿瘤发生中的作用; 2）增加内布拉斯加州牙科学校的研究概况，最终目标是在NIH资助下进入全国顶级牙科学校;最重要的是，3）为有前途的年轻教师的发展做出贡献，使他们成为科学界的杰出成员，这一点可以从NIH的大量资助中得到证明，出版重要手稿，为审查小组提供服务，并邀请在全国各地发言。 为了实现这些目标，我们将建立必要的基础设施，包括：1）一个有组织的中心，包括一名专职主任，一名助理，一个行政咨询理事会，一组忠诚的导师，一个外部咨询理事会，和一组有才华的项目领导人; 2）一个集中在细胞信号的相互关联的研究项目的集合;和3）发展计划，旨在加强和维持中心，这将包括一个研讨会计划，研究生奖学金和种子赠款计划。 我们得到了所有三个机构的大力支持，并制定了一项计划，以在COBRE资金到期时维持该计划。参与该项目的PI和导师致力于在内布拉斯加州牙科学院内发展辅导文化。此外，该中心的形成所产生的合作环境将加强内布拉斯加州牙科学校的研究基础设施。因此，我们实现所有目标的机会非常高。

DESCRIPTION (provided by applicant): This COBRE application proposes to establish a Center for Cellular Signaling that will augment and strengthen the research capacity within the Dental Schools in Nebraska. The Center will include scientists from three nearby research universities in Nebraska: University of Nebraska Medical Center, University of Nebraska at Lincoln and Creighton University. The objectives of the Center are 1) to expand the current focus on cellular signaling, with a concentration on its role in tumorigenesis; 2) to increase the research profile of Nebraska's dental schools, with the ultimate goal of being included in the top dental schools in the country in NIH funding; and, most importantly, 3) to contribute to the development of promising young faculty, so that they will become prominent members of the scientific community as evidenced by significant NIH funding, publication of important manuscripts, service on review panels and invitations to speak across the country. To accomplish these goals we will create the necessary infrastructure, which will consist of 1) An organized Center that includes a dedicated director aided by an assistant, an Administrative Advisory Council, a group of committed mentors, an External Advisory Council, and a group of talented project leaders; 2) A collection of inter-related research projects focused on cellular signaling; and 3) A program of development, designed to enhance and sustain the Center, that will include a seminar program, graduate student stipends and a seed grant program. We have strong support from all three institutions and a plan in place to sustain the program when the COBRE funding expires. The PI and mentors involved in this project are committed to developing a culture of mentoring within the Colleges of Dentistry in Nebraska. In addition, the collaborative environment resulting from the formation of the Center will enhance the research infrastructure within Nebraska's Dental Schools. Thus, the chances we will meet all our goals are very high.