Nebraska Center for Cellular Signaling

描述(由申请人提供)： Cobre的这项申请建议建立一个细胞信号传递中心，以增强和加强内布拉斯加州牙科学校的研究能力。该中心将包括来自内布拉斯加州附近三所研究型大学的科学家：内布拉斯加大学医学中心、内布拉斯加大学林肯分校和克雷顿大学。该中心的目标是1)扩大目前对细胞信号的关注，集中于其在肿瘤发生中的作用；2)提高内布拉斯加州牙科学校的研究形象，最终目标是被纳入NIH资助的全国一流牙科学校；以及最重要的是，3)促进有前途的年轻教师的发展，这样他们将成为科学界的杰出成员，NIH的大量资金、发表重要手稿、审查小组服务和在全国各地演讲的邀请就是证明。 为了实现这些目标，我们将创建必要的基础设施，其中包括1)一个有组织的中心，其中包括一名助理协助的专门主任、一个行政咨询委员会、一组尽职尽责的导师、一个外部咨询委员会和一组有才华的项目负责人；2)一系列相互关联的、专注于蜂窝信号的研究项目；以及3)一个旨在加强和维持该中心的发展计划，其中将包括研讨会计划、研究生津贴和种子资助计划。 我们得到了所有三家机构的大力支持，并制定了在Cobre资金到期后继续实施该计划的计划。参与这个项目的PI和导师致力于在内布拉斯加州的牙科学院内发展一种导师文化。此外，该中心的成立所产生的合作环境将加强内布拉斯加州牙科学校的研究基础设施。因此，我们实现所有目标的机会非常高。

DESCRIPTION (provided by applicant): This COBRE application proposes to establish a Center for Cellular Signaling that will augment and strengthen the research capacity within the Dental Schools in Nebraska. The Center will include scientists from three nearby research universities in Nebraska: University of Nebraska Medical Center, University of Nebraska at Lincoln and Creighton University. The objectives of the Center are 1) to expand the current focus on cellular signaling, with a concentration on its role in tumorigenesis; 2) to increase the research profile of Nebraska's dental schools, with the ultimate goal of being included in the top dental schools in the country in NIH funding; and, most importantly, 3) to contribute to the development of promising young faculty, so that they will become prominent members of the scientific community as evidenced by significant NIH funding, publication of important manuscripts, service on review panels and invitations to speak across the country. To accomplish these goals we will create the necessary infrastructure, which will consist of 1) An organized Center that includes a dedicated director aided by an assistant, an Administrative Advisory Council, a group of committed mentors, an External Advisory Council, and a group of talented project leaders; 2) A collection of inter-related research projects focused on cellular signaling; and 3) A program of development, designed to enhance and sustain the Center, that will include a seminar program, graduate student stipends and a seed grant program. We have strong support from all three institutions and a plan in place to sustain the program when the COBRE funding expires. The PI and mentors involved in this project are committed to developing a culture of mentoring within the Colleges of Dentistry in Nebraska. In addition, the collaborative environment resulting from the formation of the Center will enhance the research infrastructure within Nebraska's Dental Schools. Thus, the chances we will meet all our goals are very high.