Older Americans Independence Center

描述（由申请人提供）：本提案旨在在约翰霍普金斯医疗机构建立一个美国老年人独立中心。该中心的重点是通过开发干预措施来预防或改善虚弱和许多严重的不良后果，从而促进体弱老年人的独立。为了实现这一目标，一个由本机构多个部门和项目的高级和初级研究人员组成的多学科小组，提议通过本OAIC实施1。领导小组将刺激、领导和维持一个全校范围的跨学科研究项目，研究虚弱、病因和治疗机会；2. 基础设施和方法的发展对建立下一代老年人虚弱研究至关重要；3. 支持优秀的初级教师的职业发展，致力于研究将导致虚弱的治疗和预防的职业生涯；和4。培养和支持试点研究，为研究者发起和资助的长期脆弱性研究提供基础。审计协调会将提供至关重要的支持，将该机构已有的大量优势组织成一项统一和有力的努力，旨在制定针对脆弱的干预措施。它旨在确保基础研究和临床/基于人群的研究之间的多学科转化，并将两者转化为虚弱治疗的发展。这种有组织的基础设施和科学领导可以作为我们自己的机构和其他机构在衰老虚弱研究领域的研究人员的建议和合作的来源。OAIC将在行政上由约翰霍普金斯大学老龄化与健康中心领导，并由所有致力于老龄化研究的机构项目强有力的领导和参与；它还将包括以前未参与脆弱性研究但已通过本提案的规划过程对这项工作作出承诺的领导人和调查人员。基于医疗机构对统一和加强老龄化研究并突出其对整个机构的重要性的优先事项，OAIC具有坚定的机构承诺。总体而言，它旨在引领新的深度和强度的研究，以改善结果并促进体弱老年人的独立性。

DESCRIPTION (provided by applicant): This proposal seeks to establish an Older Americans Independence Center at the Johns Hopkins Medical Institutions. The focus of this center is to promote independence for frail older adults through the development of interventions to prevent or ameliorate frailty and the many serious, adverse outcomes that frail older adults are at risk for. To accomplish this, a multidisciplinary group of senior and junior investigators, in multiple Departments and Programs at this institution, propose to implement, through this OAIC, 1. the leadership group that will stimulate, lead and sustain a University-wide interdisciplinary research program investigating frailty, its etiology and opportunities for treatment; 2. the infrastructure and methodologic development essential to creating the next generations of research on frailty in older adults; 3. to support the career development of outstanding junior faculty committed to research careers that will lead to treatments for frailty and its prevention; and 4. to cultivate and support pilot studies that will provide the basis for investigator-initiated and funded research on frailty over the long run. The OAIC would provide the support critical to organizing the substantial strengths already at this institution into a unified and potent effort directed at developing interventions for frailty. It is designed to ensure multidisciplinary translation between basic and clinical/population-based research, and of both into development of treatments for frailty. This organized infrastructure and scientific leadership can serve as a source of advice and collaborations to investigators at our own institution and at other institutions in the area of research on frailty in aging. The OAIC will be administratively led by, and housed in, the Johns Hopkins Center on Aging and Health, with strong leadership and participation by all of the institutional programs committed to aging research; it will also incorporate leaders and investigators not previously involved in research on frailty but who have made a commitment to this work through the planning process for this proposal. This OAIC has strong institutional commitment, based on the priority at the Medical Institutions for the unification and strengthening of aging research and spotlighting its importance for the entire institution. Overall, it is designed to spearhead a new depth and intensity of research to improve outcomes and promote independence for frail, older adults.