Gene therapy to improve corneal graft survival

我们的工作目标是改善因角膜疾病而失明或严重视力受损的患者的预后。这类患者可以通过角膜移植恢复视力，但许多移植手术失败。角膜移植失败可能是因为不想要的免疫反应，因为血管生长到移植物中，或者因为一些角膜细胞死亡。我们计划在角膜移植之前，在实验室将基因转移到供体角膜，以避免这种失败。

The goal of our work is to improve outcomes for patients who are blind or seriously visually impaired as a result of corneal disease. Such patients can regain vision through a corneal transplant, but many such transplants fail. A corneal graft may fail because of an unwanted immune response, because blood vessels grow into the graft, or because some corneal cells die. We plan to transfer genes to the donor cornea in the laboratory, prior to corneal transplantation, to avoid such failure.