DNA Nanosensors for Metal Ion Cancer Biomarkers

癌症是主要的死亡原因，仅在英国每年造成的经济影响估计就达76亿GB。癌症诊断得越早，治疗往往就越成功。我们正在开发基于可编程DNA纳米设备的癌症诊断解决方案，这些设备能够检测、放大和报告患者血液中的癌症标志物。该项目将开发检测金属离子浓度升高的DNA纳米设备--这可能是癌症发生和发展的指标。这将通过实验和计算相结合的方法来实现。

Cancer is a major cause of death with an estimated economic impact of £7.6bn per year in the UK alone. The earlier cancers are diagnosed the more successful therapies tend to be. We are developing diagnostic solutions for cancer based on programmable DNA nanodevices that are able to detect, amplify and report cancer markers in patient blood. This project will develop DNA nanodevices that detect raised concentrations of metal ions - a possible indicator for cancer onset and progression. This will be achieved through a combination of experimental and computational methods.