Pathogenesis of Leishmaniasis:Host,Parasite and Vector

描述(由申请人提供)：这项工作的主要目的 计划是进行流行病学、临床、免疫学和遗传学 研究扩大我们对内脏的发病机制和控制的知识， 皮肤和粘膜利什曼病。UFBA、UFRN、Fiocruz、热带 医学研究中心联合体成立于1996年，现在已经建立了一个 研究人员之间的高度协同和富有成效的协作 巴西东北部的主要学术中心，这些疾病在那里流行。 总的语用主题是确定宿主的作用(免疫学 反应、遗传学)、病原体(遗传和表型标记)和 环境(沙蝇)因素在疾病表现和不良结局中的作用。 这些研究将有助于确定新的形式的 控制和改善疾病结局的干预措施，由于这些常见的 地方病。“粘膜中的宿主和寄生因素”项目 利什曼病“，将决定宿主免疫反应所起的作用 和遗传学，以及寄生虫的多态，在推动临床 粘膜利什曼病的转归。项目“人类免疫反应对 ，将评价蛇床子素的唾液效果如何 产品在最初对利什曼原虫的宿主免疫反应中是如何 对这些产物已建立的宿主免疫反应会影响疾病的结局。 项目“内脏利什曼病的疾病决定因素”，将尝试 确定感染的特定宿主遗传和环境决定因素 一个家庭队列中的疾病进展在一个地区进行了前瞻性跟踪 L为查加西特有种。宿主免疫反应在疾病中起着重要作用 利什曼病的控制。这个项目将探索一个新的领域 通过评估唾液的免疫学反应来评估寄生虫宿主的相互作用 腺体产物与查加西乳杆菌感染的临床结局相关。 重点将放在对粘膜发病机制的理解上。 利什曼病，这最终将有助于新的治疗来源和 采取预防措施，减轻利什曼病的负担。

DESCRIPTION (provided by applicant): The main objective of this program is to perform epidemiological, clinical, immunological and genetic studies to expand our knowledge of the pathogenesis and control of visceral, cutaneous and mucosal leishmaniasis. The UFBA, UFRN, FIOCRUZ, Tropical Medicine Research Center consortium was formed in 1996 and has now built a highly synergistic and productive collaboration among researchers from the major academic centers in Northeast Brazil where these diseases are endemic. The overall pragmatic theme is to determine the role of host (immunological response, genetics), pathogens (genetical and phenotypic markers) and environment (sand fly) factors in disease expression and adverse outcome. These studies will contribute to the identification of new forms of interventions to control and ameliorate disease outcomes due to these common endemic diseases. Project "Host and Parasite Factors in Mucosal Leishmaniasis", will determine the roles played by the host immune response and genetics, as well as parasite polymorphism, in driving the clinical outcome to mucosal leishmaniasis. Project "Human Immunological Responses to Phlebotomine Saliva", will evaluate how the effect of phlebotomine's salivary products in the initial host immune response to Leishmania and how the established host immune response to these products influence disease outcome. Project "Determinants of Disease in Visceral Leishmaniasis", will attempt to identify specific host genetic and environmental determinants of infection and disease progression in a family cohort followed prospectively in an area endemic for L chagasi. Host immunological response plays an important role in the control of leishmaniasis. This project will explore a new area in the parasite host interaction by evaluating how immunological response to salivary gland products correlate with clinical outcome of L. chagasi infection. Emphasis will be placed on the understanding of the pathogenesis of mucosal leishmaniasis, which eventually will contribute to new source of therapy and prophylactic measures to decrease the burden of this leishmaniasis.