MRI-Based Elasticity Imaging

组织弹性被广泛认为与疾病密切相关，特别是乳腺癌， 体检在乳腺癌筛查中占有突出的地位。因此，一个相当大的 已经出现了开发和评估用于测量和成像的新概念的技术努力 与乳房组织的机械特性相关的参数。项目I，磁共振 弹性成像（MRE）利用相差技术对感应谐波机械波进行编码 在定制梯度期间将运动转换为相位累积，以在三个 在MR采集分辨率或接近MR采集分辨率处从其导出机械特性估计的尺寸。 在本供资期内，项目一成功地实现了一种可靠的地雷危险教育技术， 在临床乳腺检查期间有限地部署，以证明可行性，提供初步的 正常乳房的机械性能的估计，并强调提取更多的机会 复杂的力学行为现有的MRE方法已准备好进行系统的临床部署， 将用于研究计划，包括（a）临床评价，（B）持续技术进步， (c)组织病理学相关性开始，以确定力学性能对比的生物学特征。 继续开展项目一的具体目标包括：（1）发展地雷危险教育驱动和重建 技术来估计乳腺组织中的粘弹性力学行为，（2）图像的优化 采集序列和方法，以减少检查时间（3）探索剪切模量和粘弹性 在乳房切除术标本中， 可用于空间采样和定向成像体积，以及（4）参与临床研究设计 由临床中心执行，针对建议活检的筛查异常、可触及肿块 临床乳腺检查和接受新辅助治疗的局部晚期疾病的初步检查。如果 如果这些目标取得成功，预计将产生足够的证据，令人信服地估计 磁共振教育有助于鉴别诊断，并提供试验数据支持治疗预后， 治疗监测，这将为未来启动更大规模的MRE临床试验提供信息。

Tissue elasticity is widely held as being strongly associated with disease, especially breast malignancy given the prominent place that physical examination holds in breast cancer screening. As a result, a sizeable technology effort has emerged to develop and evaluate new concepts for measuring and imaging parameters related to the mechanical characteristics of breast tissue. Project I, Magnetic Resonance Elastography (MRE), exploits phase contrast techniques to encode induced harmonic mechanical wave motion into phase accumulations during customized gradients to map the full displacement field in three dimensions from which mechanical property estimates are derived at or near the MR acquisition resolution. During the current funding period, Project I has successfully realized a robust MRE technique which has been deployed on a limited basis during clinical breast exams to demonstrate feasibility, provide preliminary estimates of the mechanical properties of normal breast, and highlight opportunities for extracting more complex mechanical behaviors. The existing MRE method is ready for systematic clinical deployment and will be used in a research plan consisting of (a) clinical evaluation, (b) continued technical advancement and (c) histopathological correlation to begin to identify the biological signatures of mechanical property contrast. The specific aims for continuation of Project I include (1) development of MRE driving and reconstruction techniques to estimate viscoelastic mechanical behavior in breast tissue, (2) Optimization of image acquisition sequences and methods to reduce exam time (3) exploration of shear modulus and viscoelastic property correlations with histopathological analyses in mastectomy specimens where adequate tissue is available to spatially sample and orient the imaged volume, and (4) participation in the clinical study designs executed by the Clinical Core targeting screening abnormalities recommended for biopsy, palpable masses on clinical breast exams and pilot exams of locally-advanced disease receiving neoadjuvant therapy. If successful, these aims are expected to generate evidence sufficient to estimate convincingly the potential of MRE to contribute to differential diagnosis, and pilot data in support of a role in treatment prognosis and therapy monitoring which will inform decisions on the initiation of larger clinical trials with MRE in the future.