Mapping the Mechanical Properties of the Diabetic Foot

绘制糖尿病足的机械特性图

• 批准号: 6873622
• 负责人: JOHN B WEAVER
• 金额: $ 33.32万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6873622
• 关键词: adipose tissue; amputation; bioenergetics; biomechanics; clinical research; diabetes mellitus; diabetic neuropathy; foot; human subject; infection; magnetic resonance imaging; shear stress; ulcer

DESCRIPTION (provided by applicant): Amputation of the foot is one of the most serious problems in the care of diabetics both in terms of the cost to the patient and in terms of the cost to the health care system. Foot infection accounts for 20% of hospital admissions in diabetic patients. There were approximately 86,000 amputations related to diabetes in 1999. The annual treatment cost of amputees within this group was estimated at $1.2 billion by the Center for Disease Control in 1997. This number is going to escalate because the overall prevalence of diabetes, now involving 16 million Americans, is approaching epidemic scale. The emphasis is on early intervention and prevention that in turn, depends on early detection and understanding the development of foot infections. The progression of diabetes to infection and amputation is difficult to follow because there are many factors contributing to infection. However, neuropathy generally leads to ulcers and infection. Our hypothesis is that changes in the intrinsic mechanical properties of the foot contribute to the alterations that lead to callus formation and ulceration. We will develop methods to image the intrinsic mechanical properties of the soft tissues of the foot in vivo. Current methods can not separate the intrinsic properties from the shape and structure and the intrinsic properties are more directly tied to the progression of a metabolic disease like diabetes. The intrinsic mechanical properties we will map throughout the plantar soft tissues include the: shear modulus, Poisson's ratio, and damping coefficient. There are several potential benefits to clinical medicine: early characterization of diabetic damage leading to ulceration and quantitative characterization of atrophic fat pads. The potential benefits to basic science include characterization of normal and abnormal fat pads for numerical models of the foot during ambulation and understanding the mechanisms through which diabetes degrades the plantar fat pads and other soft tissues.

描述（由申请人提供）：足部截肢是糖尿病患者护理中最严重的问题之一，无论是对患者的成本还是对医疗保健系统的成本。足部感染占住院糖尿病患者的20%。1999年，大约有86,000例截肢与糖尿病有关。据1997年疾病控制中心估计，这一群体中截肢者每年的治疗费用为12亿美元。这个数字还会上升，因为糖尿病的总体患病率，现在涉及1600万美国人，正接近流行病的规模。重点是早期干预和预防，这反过来又取决于早期发现和了解足部感染的发展。