Novel Techology for Early Indentification of Surgical Infections

摘要： 手术后感染很常见。快速识别感染至关重要， 并发症包括再入院、植入物失效或败血症。早期检测可以让培养物有时间 运行和简单的抗生素是有效的。医疗保险和医疗补助服务中心认识到， 这一问题的性质，并于2015年开始对手术重新入院实施重大处罚。此外，本发明还提供了一种方法， 早期治疗增加了外科植入物和修复术保持活力的可能性，因为它们 如果发生感染，通常必须取出或更换。 炎症是感染最早的生理标志物，但其来源多，且局部炎症 是正常伤口愈合所必需的然而，手术部位感染可能与正常感染不同， 通过监测手术部位局部炎症的特征和时间进程来监测伤口愈合。 炎症从伤口愈合和低水平的细菌感染开始在数小时内和减弱 在手术后的几天内，当伤口愈合的增殖期开始时，完全愈合。 感染引起的炎症单调增加，并且可以达到比正常愈合高得多的水平。所以 我们相信，通过精确追踪两个局部炎症标志物，可以早期识别感染： 细胞因子IL-6和局部温度。我们建议使用新型磁性纳米粒子探针进行比较， 正常愈合与感染的局部IL-6浓度和温度变化。我们假设 随着时间的推移，测量这些炎症标志物的局部水平将有助于检测手术感染。 这种新颖的技术可能导致一种便宜、简单的用于早期诊断的护理点测量系统。 检测和治疗外科感染。

Abstract: Infections are common following surgery. It is critically important to identify infections quickly to avoid complications including readmission, implant failure or sepsis. Early detection allows time for cultures to be run and simple antibiotics to be effective. The Centers for Medicare & Medicaid Services recognize the serious nature of the problem and in 2015 started imposing significant penalties for surgical readmissions. In addition, early treatment enhances the probability that surgical implants and prosthetics remain viable because they usually have to be removed or replaced if infection takes hold. Inflammation is the earliest physiologic marker of infection, but it has many sources, and local inflammation is necessary for normal wound healing. Surgical site infection, however, may be distinguishable from normal wound healing by monitoring the character and time course of local inflammation at the surgical site. Inflammation from wound healing and low levels of bacterial infection begins within hours and abates completely within a few days after surgery, when the proliferative phase of wound healing begins. Inflammation from infection increases monotonically and can reach far higher levels than normal healing. So we believe that infection can be identified early by precisely tracking two local markers of inflammation: cytokine IL-6 and local temperature. We propose to use novel magnetic nanoparticle probes to compare changes in the local concentration of IL-6 and temperature for normal healing vs. infection. We hypothesize that measuring the local level of these inflammatory markers over time will aid detection of surgical infection. This novel technology may lead to an inexpensive, simple, point of care measurement system for early detection and treatment of surgical infections.