SPECT SCANNER: CARDIOLOGY, ONCOLOGY, INFECTIOUS DIS

该子项目是利用由NIH/NCRR资助的共享仪器赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是用于资助的，不一定是研究者的机构。描述（由申请人提供）：该共享仪器提案用于采购新的Siemens Symbia T SPECT-CT系统。我们目前有一些正在进行的研究项目，将大大受益于专用的研究扫描仪，有能力进行单光子发射计算机断层扫描（SPECT），以及允许解剖映射和相关性，和衰减校正的功能图像。这样的扫描仪不仅将加强目前测量大脑功能各个方面的研究，而且将使我们能够大大扩展该领域研究项目的类型。此外，所提出的扫描仪在CT扫描仪的质量方面比以前可用的扫描仪提供了实质性的改进。该扫描仪还有几个软件程序，可帮助使用和整合SPECT和CT扫描。我们目前正在进行研究，测量脑血流和几个神经递质系统，利用脑SPECT成像研究神经和精神疾病以及激活状态。对神经和精神疾病的研究包括与帕金森病和其他运动障碍、可卡因成瘾、抑郁、焦虑和夜食综合征有关的研究。激活研究目前包括疼痛感知和安慰剂效应的研究。我们的放射化学小组一直致力于开发新的放射性药物，这些药物将用于研究大脑生理学的许多方面。最近的研究包括测量血清素转运体和检测与阿尔茨海默病相关的病理生理变化的示踪剂。所要求的扫描仪对于继续这些研究、开发新的放射性药物以及提供有利于纳入许多新研究者的成像环境至关重要。所要求的扫描仪还能够执行全身平面和SPECT成像，这对于新放射性药物的生物分布研究以及心脏病学、肿瘤学和传染病的研究是必要的。总的来说，这种扫描仪将成为我们目前和未来研究计划的主要工具，重点是脑SPECT成像，但也有可能包括许多其他类型的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): This shared instrumentation proposal is for the acquisition of a new Siemens Symbia T SPECT-CT system. We currently have a number of ongoing research projects that would benefit substantially from a dedicated research scanner that had the capability to perform single photon emission computed tomography (SPECT) as well as allow for anatomical mapping and correlation, and attenuation correction of the functional images. Such a scanner will not only enhance the present studies that measure various aspects of cerebral function, but will allow us to greatly expand the number of types of research projects in this area. Furthermore, the proposed scanner provides substantial improvements in the quality of the CT scanner than previously available. This scanner also has several software programs that aid in the use and integration of the SPECT and CT scans. We currently perform studies measuring cerebral blood flow and several neurotransmitter systems utilizing brain SPECT imaging to study neurological and psychiatric conditions as well as activation states. Studies of neurological and psychiatric conditions include those related to Parkinson's disease and other movement disorders, cocaine addiction, depression, anxiety, and night eating syndrome. Activation studies currently include the study of pain perception and the placebo effect. Our radiochemistry group is continually working on developing new radiopharmaceuticals that will have applications for studying many aspects of cerebral physiology. The most recent include tracers to measure the serotonin transporter and detect pathophysiological changes associated with Alzheimer's disease. The requested scanner is critical for continuing these studies, developing new radiopharmaceuticals, and providing an imaging environment conducive to including many new investigators. The requested scanner also has the ability to perform whole body planar and SPECT imaging which is necessary for biodistribution studies of new radiopharmaceuticals, as well as research studies in cardiology, oncology, and infectious disease. Overall, this scanner will become a major tool for our present and future research programs with a focus on brain SPECT imaging, but also the potential to include many other types of studies.