New cold-water enzymes from polar metagenomes

该项目将采用几种方法来确定用于洗涤剂和其他应用的新的突破性酶：（1）该项目将充分研究现有的候选酶及其结构/活性关系，（2）将收集新的样品以进行挖掘以鉴定和产生新的候选酶库，以及（3）从上述活动中产生的先导分子将被选择用于涉及公共数据库搜索的同系物研究，该大学现有的宏基因组，以确定相关的分子，并产生一个不同的面板的变异特征和应用测试。最有希望的线索将被推进到小规模的消费者研究。

This project will pursue several approaches to identify new breakthrough enzymes for detergent and other applications: (1) the project will fully characterise an existing candidate enzyme and its structure/activity relationship, (2) new samples will be collected be mined to identify and produce new libraries of enzyme candidates and (3) lead molecules emerging from the above activities will be selected for homologue studies involving searches of public databases, the university's existing metagenomes to identify related molecules and produce a diverse panel of variants for characterisation and application testing. The most promising leads will be advanced to small-scale consumer research.