ANXIETY, DEPRESSION AND ASTHMA IN PUERTO RICAN YOUTH

描述（由申请人提供）：本申请响应NIMH项目公告（PA） 02-047，精神和其他身体疾病共病研究。文献中描述了儿童和青少年精神和心理问题与家长报告的哮喘之间的联系，有一些证据表明，在波多黎各青年中，哮喘的患病率及其与精神障碍的联系尤其显著。然而，以往研究的方法学设计很大程度上局限于临床样本的使用、横断面研究以及对青少年精神疾病或哮喘的非标准化或其他折衷措施的使用。这些限制阻碍了对社区关联的解释。拟议的研究克服了许多这些限制，并将确定波多黎各青年中焦虑和抑郁障碍与哮喘之间的关联程度，还将确定儿童和青少年样本中照顾者的精神障碍与哮喘风险之间的关联。此外，它将确定照顾者精神病理、压力源、功能与儿童哮喘管理之间的潜在关系。这项研究建立在1999年至2001年之前收集的两波波多黎各青年数据（R01-MH054827; Dr. gloria Canino）的基础上。它将从最初的队列中收集700名青少年分层样本，收集关于儿童/青少年和照顾者精神疾病、哮喘患病率和严重程度以及心理社会问题的新的第三波数据。我们还将从700名受试者中抽取200名分层样本进行肺活量测定和病历回顾。拟议的研究将使我们能够开始调查哮喘和精神障碍合并症的机制和临床管理后果。总的来说，这项研究将为西班牙裔青年的两个主要公共卫生问题，心理健康和哮喘提供有用的信息，并开始调查这两个关键公共卫生问题之间的联系。

DESCRIPTION (provided by applicant): This application responds to NIMH Program Announcement (PA) 02-047, Research on Co-Morbid Mental and Other Physical Disorders. Associations between child and adolescent psychiatric and psychological problems and parent reports of asthma have been described in the literature, and there is some evidence that the prevalence of asthma and its association with mental disorders is particularly striking in Puerto Rican youth. However, the methodological designs of previous studies have been largely limited to the use of clinical samples, cross-sectional studies, and the use of non-standardized or otherwise compromised measures of psychiatric disorders or asthma in youth. These limitations prevent interpretation of the associations in the community. The proposed study overcomes many of these limitations and would establish the magnitude of associations between anxiety and depressive disorders and asthma in Puerto Rican youth, and it would also determine the associations between caregivers' mental disorders and risk for asthma in the sample of children and adolescents. Further, it would determine the prospective relations between caregiver psychopathology, stressors, functioning and the management of childhood asthma. The study builds on two previously collected waves of data of Puerto Rican youth (R01-MH054827; Dr. Glorisa Canino), from 1999-2001. It would collect a new, third wave of data on child/adolescent and caregiver psychiatric disorders, asthma prevalence and severity, and psychosocial problems in a stratified sample of 700 youth from the original cohort. We will also take a stratified sample of 200 of the 700 subjects for spirometry testing and medical chart review. The proposed study will allow us to begin to investigate the mechanisms and clinical management consequences of co-morbid asthma and mental disorders. Overall, this study will provide useful information on two major public health problems for Hispanic youth, mental health and asthma, and begin to investigate the links between theses two critical public health issues.