Regulation of Filamentous Growth in Yeast

描述（由申请人提供）：白色念珠菌是人类最常分离的真菌病原体之一。它可以在出芽酵母、假菌丝和菌丝生长形式之间经历可逆的形态发生转变。其独特的能力，从酵母到菌丝生长响应各种环境信号的转换不仅是固有的致病性，但也提供了一个很好的范式来理解信号通路如何协调生长和发育。本研究的目的是了解菌丝信号通路如何整合外部信号与时间和空间线索，以产生线状菌丝。有五个具体目的：(1)在菌丝诱导条件的初始反应中激活菌丝信号。(2)细胞周期对菌丝信号的调控。(3)细胞极性对菌丝信号转导的调控。(4)鉴定控制细胞极性的菌丝信号传导目标。(5)顶端细胞特异性定位和线性细胞分裂。

DESCRIPTION (provided by applicant): Candida albicans is one of the most frequently isolated fungal pathogens of humans. It can undergo reversible morphogenetic transitions among budding yeast, pseudohyphal, and hyphal growth forms. Its unique ability to switch from yeast to hyphal growth in response to various environmental signals not only is inherent to its pathogenicity, but also provides an excellent paradigm to understand how signaling pathways coordinate growth and development. The objectives of this research are to understand how hyphal signaling pathways integrate external signals with temporal and spatial cues to generate linear hyphal filaments. There are five specific aims: (1) Activation of hyphal signaling during the initial response to hyphal inducing conditions. (2) Regulation of hyphal signaling by cell cycle. (3) Regulation of hyphal signaling by cell polarity. (4) Identification of targets of hyphal signaling that control cell polarity. (5) Apical cell-specific localization and linear cell division.