Genome-wide investigation of bovine respiratory virus infection and host defence

牛呼吸道疾病（BRD）-通常称为“运输热”-每年影响数百万饲养场小牛，除了造成重大的动物福利问题外，还是全世界经济损失的主要原因。BRD由多种病原体引起，包括呼吸道病毒感染，如牛呼吸道合胞病毒（BRSV）、牛副流感病毒3型（BPIV 3）、牛疱疹病毒1型（BoHV 1）。这些病原体对呼吸道细胞造成损害，阻碍肺部清除，使小牛易受继发性细菌感染。因此，需要更好地了解病毒生物学，特别是哪些宿主因素是成功感染的关键。同样，需要了解宿主防御系统如何试图限制其复制，以更好地为开发新的治疗方法或如何开发更具可持续性和适应力的动物提供信息。

Bovine respiratory disease (BRD) - commonly known as "shipping fever" - affects millions of feedlot calves every year and, in addition to causing significant animal welfare issues, is a major cause of economic loss throughout the world. BRD is caused by a complex of pathogens including infection with respiratory viruses such as bovine respiratory syncytial virus (BRSV), bovine parainfluenza virus 3 (BPIV3), bovine herpes virus 1 (BoHV1). These pathogens cause damage to cells of the respiratory tract that hinders pulmonary clearance leaving calves susceptible to secondary bacterial infections. Therefore, a better understanding of virus biology, particularly what host factors are key to successful infection is needed. Likewise, knowledge of how the host defence system attempts to limit their replication is required to better inform the development of new therapeutic approaches or how to develop more sustainable and resilient animals.