Light mediated carbonylation reactions using CO 'surrogates'

一氧化碳“替代物”分子可用于羰基化反应中以减轻使用有毒且易燃的CO的风险。此类CO释放分子还可用于方便地控制小规模反应的CO化学计量，并且在处理CO的基础设施不可用的情况下。该项目旨在开发新型复合物，这些复合物能够在被紫外线激活时捕获并释放CO。迄今为止，大多数CO替代分子通过热能触发释放CO，然而，光催化反应范围的不断扩大意味着光激活释放CO过程将变得更加重要。本项目旨在将联合收割机用于光介导的羰基化反应，并将该系统应用于生成含羰基分子（醛、酰胺、酯、内酰胺等）。与制药和农用化学品行业相关的信息。

Carbon monoxide 'surrogate' molecules can be used in carbonylation reactions to mitigate the risk of using toxic and flammable CO. Such CO releasing molecules can also be used to conveniently control CO stoichiometry for small scale reactions and where the infrastructure for handling CO is not available. This project seeks to develop novel complexes that are capable of trapping and then releasing CO when activated by UV light. To date, most CO surrogate molecules are triggered to release CO via thermal energy, however, the growing range of photocatalytic reactions mean that light activated releasing CO processes will become more important. This project aims to combine flow chemistry for light mediated carbonylation reactions and apply the system to generating carbonyl containing molecules (aldehydes, amides, esters, lactams etc.) that are relevant to the pharma and agrochemical sectors.