Within-host drivers of zoonotic disease dynamics

个体是多种生物的宿主，包括蠕虫、原生动物、细菌和病毒的寄生群落，但每种成分如何相互作用尚不清楚。我们认为，每个主机内组件会随着主机内驱动因素的变化而波动，但也会随着环境的变化而波动。相互作用的后果是重要的，特别是如果我们考虑到人畜共患寄生虫和病原体是相互作用系统的一部分。当宿主数量和相互作用发生迅速而剧烈的变化时（例如，在环境恢复或对宿主进行药物治疗期间），宿主内稳态的变化尤为重要（且未知）。在这里，我们将重点了解环境变化与农业生态系统中宿主内寄生虫相互作用的交集，包括野生动物宿主和牲畜作为人畜共患病的宿主；后者是因为它们受到寄生虫/病原体的治疗，自然会扰乱寄生虫群落。我们将对宿主微生物群、核体和病毒组进行采样，以了解寄生虫群落的波动如何影响人畜共患病原体（引起人类疾病的动物病原体）的流行以及随后对公共卫生的风险

Individuals are host to a diverse set of organisms, including parasite communities of helminths, protozoa, bacteria, and viruses, but how each component interacts is unclear. We propose that each within-host component fluctuates in response to within-host drivers, but also to changes in the environment. The consequences of interaction are important, especially if we consider that zoonotic parasites and pathogens are part of that interacting system. Changes in within-host homeostasis is particularly important (and unknown) when host numbers and interactions can change rapidly and dramatically (for example, during rewilding of the environment or drug treatment of a host). Here, we will focus on understanding the intersection of environmental changes on within-host parasite interactions in agroecosystems including wildlife hosts and livestock as reservoirs of zoonoses; the latter because they are subject to parasite/pathogen treatments that naturally perturb the parasite community. We will sample host microbiota, eurkaryome and virome to understand how parasite community fluctuations affects the prevalence of zoonotic pathogens (animal pathogens causing disease in humans) and the subsequent risk to public healt