Nocturia and Chronic Medical illness

描述(由申请人提供)： 这份申请概述了通过以患者为中心的研究生涯中期奖的支持，进一步促进我对初级临床研究人员的个人教育和指导的计划。还描述了临床研究的新方向，特别强调糖尿病与夜尿和其他下尿路症状(LUTS)的相互作用。虽然夜尿症本身不会危及生命，但它会严重影响患者的生活质量，并可能是整体健康状况不佳的指标。一些证据表明，慢性内科疾病和用于治疗这些疾病的药物可能会影响这些夜尿症和其他LUT的患病率和严重程度。试图缓解夜尿症/下尿症的医疗保健提供者面临着与在医疗疾病背景下调查和治疗夜尿症/下尿症相关的重大知识差距，因为每种疾病和合并疾病对这些下尿症的影响的程度尚不清楚。这项建议旨在正式研究糖尿病患者和非糖尿病患者的血糖控制、肾功能和下尿路感染之间的关系。这项原始研究的结果和信息丰富的流行病学数据将整合在一起，开始形成几种慢性内科疾病与夜尿症/下尿路综合征的相互作用的模型，并开发在这种情况下评估和治疗夜尿症患者的算法。所描述的项目也将产生假设，并将作为指导选择对这一研究领域感兴趣的现有和未来研究员和居民的工具。 K24奖项提供的受保护时间也将使我能够继续接受生物统计学方面的教育，并参与生物统计咨询团队的指导活动。与我提议的研究项目相一致的肾脏医学进一步教育也将是可行的，参加在Mines VA医疗中心内的教学会议。 最后，工资支持将使我能够继续并扩大我的指导努力，以造福于现在和未来的同事、研究员和住院医生。

DESCRIPTION (provided by applicant): This application outlines plans to further my personal education and mentoring of junior clinical researchers through support from a Mid-Career Award in Patient Oriented Research. A new direction in clinical research is also described, with specific emphasis on the interaction of diabetes with nocturia and other lower urinary tract symptoms (LUTS). Although not in itself life-threatening, nocturia can severely adversely affect patient quality of life and can be an indicator of poor overall health. Several lines of evidence suggest that chronic medical illnesses and medications used to treat those illnesses may affect the prevalence and severity of those nocturia and other LUTS. Healthcare providers attempting to relieve nocturia/LUTS are faced with a major knowledge gap related to the investigation and treatment of nocturia/LUTS in the setting of medical illness, as the magnitude of the effect of each illness and combined illnesses on those LUTS is unknown. This proposal seeks to formally study the relationship between glycemic control, renal function and LUTS in patients with and without diabetes. The results of this original research and informative epidemiological data will then be integrated to begin to form a model of the interaction of several chronic medical illnesses with nocturia/LUTS, and development of algorithms for the evaluation and treatment of patients with nocturia in that setting. The projects described will also be hypothesis-generating and will serve as vehicles for mentoring of current and future Fellows and Residents who choose to become interested in this line of research. The protected time afforded by the K24 award will also allow my continuing education in biostatistics, and my participation in the mentoring activities of the biostatistical consulting team. Further education in renal medicine in line with my proposed research project will also be feasible, with attendance at didactic sessions within the Mines VA medical center. Finally, salary support will allow me to continue and expand my mentoring efforts for the benefit of current and future colleagues, fellows and residents.