Growth and Physical Maturation in Cerebral Palsy

描述（由申请人提供）：此中期职业奖被要求支持理查德D.史蒂文森博士，弗吉尼亚大学（UVA）儿科副教授。 在过去的10年里，史蒂文森博士一直致力于以患者为导向的研究和指导新的研究者。他是一项重点研究工作的首席研究员，该研究工作调查了生长，营养和身体发育对脑瘫儿童（CP）健康和生活质量的重要性。本提案的研究培训、指导和临床研究目标（分别）是（1）将申请人的描述性研究的研究计划（已发现问题和趋势）过渡到临床试验，以测试改善儿童健康的假设，（2）提供临床研究方面的培训和指导（3）通过对生长、营养状况和其他次要条件的管理，最大限度地提高脑瘫儿童及其家庭的健康、参与和生活质量。 申请人正在申请K-24资金，将50%的时间用于这些追求。接下来的5年对于申请人的研究计划的巩固以及通过指导和培训新研究人员来扩大他的努力至关重要。根据上次审查的要求，这次修订大大扩大了研究培训计划。它包括在残疾人临床试验的开发和进行的课程，研究和实践。这项培训将通过注册临床研究的多学科培训计划，通过健康评估科学UVA的部门正式课程，并通过与同事的合作努力来完成。指导计划已被简化，包括（1）为住院医师，研究员和儿科，发育医学和康复学院制定以患者为导向的研究课程，利用UVA的所有资源，（2）对新研究人员进行重点指导，制定个性化的研究计划与每个学员，以及（3）指导每个学员完成离散的研究项目。该研究计划包括北美脑性瘫痪项目（NAGCPP）的一部分，重点是开发营养干预治疗和预防营养不良的临床试验。由于生长不良和营养不良是常见的，并且由于CP儿童可以被认为是残疾人的临床模型，因此这项工作对于患有发育性和后天性残疾的儿童和成人人群非常重要和高度相关。

DESCRIPTION (provided by applicant): This Mid-Career Award is requested to support the continued research development and mentoring activities of Richard D. Stevenson, MD, Associate Professor of Pediatrics at the University of Virginia (UVA). Over the past 10 years, Dr. Stevenson has shown a commitment to patient-oriented research and mentoring of new investigators. He is the principal investigator of a focused research effort investigating the importance of growth, nutrition, and physical development on the health and quality of life of children with cerebral palsy (CP). The goals of this proposal for research training, mentoring, and clinical research (respectively) are to (1) transition the applicant's research program of descriptive studies that have identified problems and trends to clinical trials that will test hypotheses toward the improvement of child health, (2) provide training and mentorship in clinical research (in general) and clinical research in persons with disabilities (specifically), and (3) maximize the health, participation and quality of life of children with CP and their families through the management of growth, nutritional status and other secondary conditions. The applicant is requesting K-24 funding to devote 50% of his time toward these pursuits. The next 5 years are critical to the consolidation of the applicant's research program and the expansion of his efforts through the mentoring and training of new investigators. The research training plan has been significantly expanded with this revision in response to the last review. It includes coursework, study, and practice in the development and conduct of clinical trials in persons with disabilities. This training will be accomplished through enrollment in the Multidisciplinary Training Program in Clinical Investigation, formal coursework through UVA's Department of Health Evaluation Sciences, and through collaborative efforts with colleagues. The mentoring plan has been simplified and includes (1) development of a patient-oriented research curriculum for residents, fellows, and faculty in pediatrics, developmental medicine and rehabilitation, using all resources available at UVA, (2) focused mentoring of the new investigators with the development of individualized research plans with each mentee, and (3) mentored completion of discrete research projects by each mentee. The research plan consists of studies that are part of the North American Growth in Cerebral Palsy Project (NAGCPP), and focuses on the development of clinical trials of nutritional interventions for the treatment and prevention of malnutrition. As poor growth and malnutrition are common, and as children with CP can be considered a clinical model of individuals with disabilities at large, this work is important and highly relevant to populations of children and adults with developmental and acquired disabilities.