Alzheimer's Disease Research Center

描述(由申请人提供)：这份提案是加州大学圣地亚哥分校的阿尔茨海默病研究中心(ADRC)与巴克研究所(Buck Institute)联合进行的为期五年的续签。该中心未来五年的主要目标将是通过轻度认知损害(MCI)的中间步骤，扩大我们的工作范围，研究从正常衰老到痴呆的转变，并研究神经退行性变的机制，这些项目将侧重于阿尔茨海默病高危老年人的功能磁共振(Bondi，项目1)，测试轴突障碍在阿尔茨海默病中的作用(Goldstein，项目2)，以及研究APP及其相互作用蛋白的细胞质结构域在突触损伤中的作用(Koo，项目3)。该中心将继续保持非常强大的临床和神经病理核心。临床核心中心将继续纵向描述大约500名受试者的特征，以研究认知和语义记忆的早期变化，并为其他研究人员和圣地亚哥社区作为一个整体提供具有良好特征的白人和西班牙裔志愿者的临床队列。临床核心还将招募受试者和控制组，以支持许多个别项目的特殊需要。该中心还将继续参与由NACC或直接由NIA资助的其他发展援助中心的合作项目。受试者还将参加多中心药物试验。来自受试者的数据将用于合作研究。此外，我们将继续在阿尔茨海默病和其他相关神经退行性疾病中进行详细的临床病理对照：路易体变异型阿尔茨海默病和额颞叶痴呆。神经疗法核心在这一努力中发挥了主导作用。该中心作为一个整体，将继续根据要求向调查人员提供脑组织、血浆、血清、DNA和脑脊液。ADRC提供了一个促进调查人员研究培训的环境，并将通过我们的小型驻留计划、会议和其他教育活动向专业和非专业社区传递信息。数据管理与生物统计学 CORE将继续为ADRC调查人员提供统计设计和分析服务，准备提交给NACC的最低数据集，并协调临床和神经病理CORE产生的数据的录入、质量控制、管理和分析。

DESCRIPTION (provided by applicant): This proposal is for a five-year renewal of the Alzheimer's Disease Research Center (ADRC) at the University of California San Diego in consortium with The Buck Institute. The major goals of the Center over the next five years will be to expand our efforts into studying the conversion from normal aging to dementia through the intermediary step of Mild Cognitive Impairment (MCI) and to study mechanisms of neurodegeneration Projects will focus on functional MRI of the elderly at risk for Alzheimer's disease (Bondi, Project 1), testing of the role of axonal disturbances in Alzheimer's disease (Goldstein, Project 2), and studying the cytoplasmic domain of APP and its interacting proteins in synapse damage (Koo, Project 3). This Center will continue to maintain extremely strong Clinical and Neuropathological Cores. The Clinical Core will continue to longitudinally characterize a cohort of approximately 500 subjects to study early changes in cognition and semantic memory, and to provide other investigators and the San Diego community as a whole with a well characterized clinical cohort of both Caucasian and Hispanic volunteers. The Clinical Core will also recruit subjects and controls to support the special needs of many of the individual projects. The Center will also continue its participation in collaborative projects with other ADCs funded through the NACC or directly from NIA. Subjects will also participate in multi-center drug trials. Data derived from subjects will be used in collaborative research. In addition we will continue to carry out detailed clinicopathological correlations in Alzheimer's disease and other related neurodegenerative diseases: Lewy Body Variant of AD and fronto-temporal dementia. The Neuropath Core has taken a lead role in this endeavor. The Center as a whole will continue to provide brain tissue, plasma, serum, DNA, and cerebrospinal fluid to investigators upon request. The ADRC provides a setting to facilitate research training of investigators and will transfer information to the professional and lay communities through our miniresidency program, conferences and other educational activities. The Data Management and Biostatistics Core will continue to provide statistical design and analysis services to ADRC investigators, prepare the minimum data set for submission to the NACC, as well as coordinate the entry, quality control, management and analysis of data generated by the Clinical and Neuropathology Cores.