CORE--DATA MANAGEMENT AND BIOSTATISTICS

这个核心的主要目标是为华盛顿大学阿尔茨海默病研究中心(ADRC)的核心和项目提供数据管理、统计遗传和生物统计支持。我们的具体目标是：(1)为项目、核心和试点项目提供数据库管理支持；(2)在统计和统计遗传设计和分析领域向华盛顿大学亚洲发展研究中心和其他亚洲发展中心的项目、核心和试点项目提供支持；(3)协助项目、核心和试点项目准备与统计和统计遗传分析有关的手稿；(4)保持主动主动地提供这种支持；以及(5)评估、发展、推广和应用适当的统计学。 项目、核心和试点项目产生的问题的统计遗传方法。核心计算机专家构建、修改和维护存储和访问ADRC数据所需的数据库，以满足核心和项目的分析需求，并能够提取数据提交给国家阿尔茨海默病协调中心。核心计算机专家还维护通过因特网访问分析计算机和数据库所需的计算机硬件和系统级软件，同时使计算机系统在安全方面保持最新，以防止未经授权的访问。核心计算机专家和研究顾问也是 可根据需要向所有核心和项目提供一些编程服务。核心统计遗传学家和生物统计学家可为所有核心和项目提供咨询和协助，涉及数据的设计、分析和解释，以及使用这种方法编写手稿。这包括评估、推广和发展新的分析方法，以及基于这种新方法的手稿创作和合著。

The primary objective of this Core is to provide data management, statistical genetic, and biostatistical support to the Cores and Projects of the University of Washington Alzheimer's Disease Research Center (ADRC). Our specific aims are: (1) To provide database management support to projects, cores and pilot projects;(2) To provide support to projects, cores and pilot projects in the areas of statistical and statistical genetic design and analysis at the UW ADRC and at other ADCs; (3) To assist projects, cores, and pilot projects in manuscript preparation relating to statistical and statistical genetic analyses; (4) To maintain a proactive approach to provision of such support; and (5) To evaluate, develop, extend, and apply appropriate statistical and statistical genetic methodologies for problems arising out of projects, cores, and pilot projects. Core computer specialists construct, modify, and maintain the databases needed to store and access the ADRC data for the analytical needs of the cores and projects, and to be able to extract data for submission to the National Alzheimer's Disease Coordinating Center. Core computer specialists also maintain the computer hardware and the systems level software needed for access to the analysis computers and to the databases via the internet, while at the same time keeping the computer systems up-to-date in terms of security, to prevent unauthorized access. Core computer specialists and research consultants are also available to provide some programming services, as needed, to all cores and projects. Core statistical geneticists and biostatisticians are available to all cores and projects for consultation and assistance regarding design, analysis, and interpretation of data, and preparation of manuscripts using such approaches. This includes evaluation, extension, and development of new analytical methodology and the authoring and coauthoring of manuscripts based on such new methods.